| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sirolimus 10.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
| Similar Terms | |
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170 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 6.1822 |
| HBA1 | hemoglobin, alpha 1 | 4.79499 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 4.70721 |
| WIF1 | WNT inhibitory factor 1 | 4.70308 |
| SQSTM1 | sequestosome 1 | 4.53413 |
| COQ8A | coenzyme Q8A | 4.20234 |
| FHL2 | four and a half LIM domains 2 | 4.17363 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 4.02074 |
| FOSL1 | FOS-like antigen 1 | 3.9761 |
| NUCB2 | nucleobindin 2 | 3.65331 |
| GLRX | glutaredoxin (thioltransferase) | 3.58342 |
| HMGA2 | high mobility group AT-hook 2 | 3.58264 |
| PRAF2 | PRA1 domain family, member 2 | 3.50835 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 3.41118 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.39743 |
| TCTN1 | tectonic family member 1 | 3.33617 |
| CTSL | cathepsin L | 3.31262 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 3.17418 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.12986 |
| DUSP4 | dual specificity phosphatase 4 | 3.11823 |
| CHMP4B | charged multivesicular body protein 4B | 3.05267 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.03922 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.99152 |
| EAPP | E2F-associated phosphoprotein | 2.9898 |
| SLC75A1 | solute carrier family 75 member 1 | 2.92777 |
| SCCPDH | saccharopine dehydrogenase (putative) | 2.91419 |
| SQOR | sulfide quinone oxidoreductase | 2.9067 |
| KDM5D | lysine (K)-specific demethylase 5D | 2.89061 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 2.88881 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.83308 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.83052 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 2.8273 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 2.80256 |
| DUSP6 | dual specificity phosphatase 6 | 2.75981 |
| CALU | calumenin | 2.74558 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 2.73142 |
| KLHL21 | kelch-like family member 21 | 2.65653 |
| TSPAN4 | tetraspanin 4 | 2.639 |
| FNDC3B | fibronectin type III domain containing 3B | 2.6259 |
| ADRB2 | adrenoceptor beta 2, surface | 2.61193 |
| ADAM10 | ADAM metallopeptidase domain 10 | 2.59167 |
| IER3 | immediate early response 3 | 2.53129 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 2.5251 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 2.50909 |
| TUBB6 | tubulin, beta 6 class V | 2.46518 |
| PRDX5 | peroxiredoxin 5 | 2.45573 |
| EGR1 | early growth response 1 | 2.44143 |
| STX1A | syntaxin 1A (brain) | 2.43988 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 2.43697 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 2.43328 |
| CBR1 | carbonyl reductase 1 | 2.40944 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 2.39816 |
| GALE | UDP-galactose-4-epimerase | 2.39705 |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | 2.36099 |
| HMOX1 | heme oxygenase 1 | 2.34907 |
| CTBS | chitobiase, di-N-acetyl- | 2.34647 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 2.3451 |
| SMAD3 | SMAD family member 3 | 2.31825 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 2.29421 |
| HBEGF | heparin-binding EGF-like growth factor | 2.29184 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 2.28729 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 2.28728 |
| GOLGA3 | golgin A3 | 2.25639 |
| UNC13D | unc-13 homolog D (C. elegans) | 2.25562 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 2.24678 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 2.2164 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 2.18845 |
| HGSNAT | heparan-alpha-glucosaminide N-acetyltransferase | 2.18181 |
| KDSR | 3-ketodihydrosphingosine reductase | 2.17695 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 2.13598 |
| TRAPPC4 | trafficking protein particle complex 4 | 2.13056 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 2.12682 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 2.10403 |
| PYGL | phosphorylase, glycogen, liver | 2.09118 |
| SUN2 | Sad1 and UNC84 domain containing 2 | 2.07596 |
| NUBPL | nucleotide binding protein-like | 2.07421 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 2.07221 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 2.06721 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 2.06586 |
| COCH | cochlin | 2.06487 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 2.04612 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 2.03689 |
| KIFBP | kinesin family binding protein | 2.03153 |
| SDC4 | syndecan 4 | 2.00894 |
| CTSW | cathepsin W | 2.00872 |
| MYL11 | myosin light chain 11 | 2.00604 |
| CD96 | CD96 molecule | 2.00594 |
| BLVRA | biliverdin reductase A | 2.00049 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | -5.68742 |
| ALDOC | aldolase C, fructose-bisphosphate | -5.54835 |
| MSMO1 | methylsterol monooxygenase 1 | -5.50603 |
| PRR15L | proline rich 15-like | -5.25901 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.35846 |
| RPIA | ribose 5-phosphate isomerase A | -4.10446 |
| HAT1 | histone acetyltransferase 1 | -3.99623 |
| SESN1 | sestrin 1 | -3.91127 |
| INSIG1 | insulin induced gene 1 | -3.78508 |
| TSC22D3 | TSC22 domain family, member 3 | -3.5661 |
| CYCS | cytochrome c, somatic | -3.26383 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -3.15305 |
| SMNDC1 | survival motor neuron domain containing 1 | -3.10754 |
| HSPB1 | heat shock 27kDa protein 1 | -3.10579 |
| ATG3 | autophagy related 3 | -3.02184 |
| NVL | nuclear VCP-like | -3.0164 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.86678 |
| PARPBP | PARP1 binding protein | -2.85416 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -2.81476 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -2.81405 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | -2.80369 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -2.80253 |
| HMG20B | high mobility group 20B | -2.80076 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -2.80069 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | -2.75714 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.73407 |
| S100A4 | S100 calcium binding protein A4 | -2.69604 |
| CIAPIN1 | cytokine induced apoptosis inhibitor 1 | -2.6784 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -2.62268 |
| CCNC | cyclin C | -2.56141 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -2.50085 |
| INTS12 | integrator complex subunit 12 | -2.49509 |
| MFAP4 | microfibrillar-associated protein 4 | -2.476 |
| CDC40 | cell division cycle 40 | -2.34981 |
| RNF38 | ring finger protein 38 | -2.32346 |
| LBR | lamin B receptor | -2.31522 |
| LMBR1 | limb development membrane protein 1 | -2.30667 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | -2.30458 |
| TTYH1 | tweety family member 1 | -2.30025 |
| IFT57 | intraflagellar transport 57 | -2.28807 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -2.25775 |
| TRIM37 | tripartite motif containing 37 | -2.2559 |
| MTO1 | mitochondrial tRNA translation optimization 1 | -2.22707 |
| ORC4 | origin recognition complex, subunit 4 | -2.22418 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | -2.22014 |
| EXOC1 | exocyst complex component 1 | -2.21335 |
| UVRAG | UV radiation resistance associated | -2.20709 |
| VPS45 | vacuolar protein sorting 45 homolog (S. cerevisiae) | -2.20421 |
| GPR88 | G protein-coupled receptor 88 | -2.20072 |
| CCDC88C | coiled-coil domain containing 88C | -2.18738 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.18285 |
| SH3D19 | SH3 domain containing 19 | -2.1764 |
| AP5M1 | adaptor-related protein complex 5, mu 1 subunit | -2.17578 |
| MTX2 | metaxin 2 | -2.1727 |
| AP1AR | adaptor-related protein complex 1 associated regulatory protein | -2.15059 |
| ZNF195 | zinc finger protein 195 | -2.14946 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.14613 |
| SLC25A12 | solute carrier family 25 (aspartate/glutamate carrier), member 12 | -2.12679 |
| BORA | bora, aurora kinase A activator | -2.1019 |
| SNX2 | sorting nexin 2 | -2.08745 |
| BLNK | B-cell linker | -2.08585 |
| USP21 | ubiquitin specific peptidase 21 | -2.08448 |
| QTRT2 | queuine tRNA-ribosyltransferase accessory subunit 2 | -2.07123 |
| SQLE | squalene epoxidase | -2.06679 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -2.06214 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -2.0556 |
| SPARCL1 | SPARC-like 1 (hevin) | -2.04758 |
| MTERF4 | mitochondrial transcription termination factor 4 | -2.04752 |
| RAB33A | RAB33A, member RAS oncogene family | -2.04387 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -2.04317 |
| THUMPD2 | THUMP domain containing 2 | -2.04301 |
| CSRP1 | cysteine and glycine-rich protein 1 | -2.04133 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.04078 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.03351 |
| DHX35 | DEAH (Asp-Glu-Ala-His) box polypeptide 35 | -2.03329 |
| NOTCH1 | notch 1 | -2.02793 |
| ZNF318 | zinc finger protein 318 | -2.02351 |
| MAIP1 | matrix AAA peptidase interacting protein 1 | -2.01774 |
| PPEF1 | protein phosphatase, EF-hand calcium binding domain 1 | -2.01609 |
| GRHL2 | grainyhead-like 2 (Drosophila) | -2.00323 |
| RASL12 | RAS-like, family 12 | -2.00214 |
| FGL2 | fibrinogen-like 2 | -2.00131 |
