CRCGN015_MCF10A.WT.HP_24H:G18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

93 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 7.77578
TCTN1 tectonic family member 1 3.74343
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.73467
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.56674
HBA1 hemoglobin, alpha 1 3.53035
KLHL9 kelch-like family member 9 3.30314
GARRE1 granule associated Rac and RHOG effector 1 3.30218
SCCPDH saccharopine dehydrogenase (putative) 3.24178
TSPAN4 tetraspanin 4 3.16239
FGFR4 fibroblast growth factor receptor 4 3.02852
FHL2 four and a half LIM domains 2 3.00058
WIF1 WNT inhibitory factor 1 2.98664
HMGA2 high mobility group AT-hook 2 2.87654
CXCL2 chemokine (C-X-C motif) ligand 2 2.76474
CEP57 centrosomal protein 57kDa 2.74457
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.74341
EVL Enah/Vasp-like 2.67251
DUSP4 dual specificity phosphatase 4 2.64209
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.5135
TNIP1 TNFAIP3 interacting protein 1 2.38872
HDLBP high density lipoprotein binding protein 2.37041
FOSL1 FOS-like antigen 1 2.33293
CUEDC2 CUE domain containing 2 2.32848
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.28858
OXCT1 3-oxoacid CoA transferase 1 2.24596
PDIA5 protein disulfide isomerase family A, member 5 2.21644
IRS2 insulin receptor substrate 2 2.19531
DUSP6 dual specificity phosphatase 6 2.17479
EGR3 early growth response 3 2.17429
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.14864
ZW10 zw10 kinetochore protein 2.14367
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.13791
CCP110 centriolar coiled coil protein 110kDa 2.12977
NT5E 5'-nucleotidase, ecto (CD73) 2.12528
RBM12B RNA binding motif protein 12B 2.11248
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.10144
GLB1L2 galactosidase, beta 1-like 2 2.06865
CHMP4B charged multivesicular body protein 4B 2.05375
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.03328
UQCRC1 ubiquinol-cytochrome c reductase core protein I 2.02176
SMAD3 SMAD family member 3 2.00784
ETV4 ets variant 4 2.00737

decreased expression

Symbol Name Standardized Value
ALDOC aldolase C, fructose-bisphosphate -4.68437
NUP85 nucleoporin 85kDa -4.29522
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.8351
PRR15L proline rich 15-like -3.82183
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.54405
SCYL3 SCY1-like 3 (S. cerevisiae) -3.41407
MRPL58 mitochondrial ribosomal protein L58 -3.29447
DDIT4 DNA-damage-inducible transcript 4 -3.20305
INSIG1 insulin induced gene 1 -3.03553
MRPS7 mitochondrial ribosomal protein S7 -2.95682
KCTD2 potassium channel tetramerization domain containing 2 -2.7899
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.74721
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.70793
SMNDC1 survival motor neuron domain containing 1 -2.69783
RBM34 RNA binding motif protein 34 -2.66724
SESN1 sestrin 1 -2.64891
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.61145
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -2.60755
TUBA4A tubulin, alpha 4a -2.58407
TRIP4 thyroid hormone receptor interactor 4 -2.54244
NLRP2B NLR family pyrin domain containing 2B -2.52283
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.51189
HSPB1 heat shock 27kDa protein 1 -2.511
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.49757
MTO1 mitochondrial tRNA translation optimization 1 -2.49187
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.4382
TBCE tubulin folding cofactor E -2.34028
S100A4 S100 calcium binding protein A4 -2.33711
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.27948
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.27572
SAP30BP SAP30 binding protein -2.26248
TMEM94 transmembrane protein 94 -2.24745
AURKA aurora kinase A -2.24376
ABHD4 abhydrolase domain containing 4 -2.15517
GTF2A2 general transcription factor IIA, 2, 12kDa -2.13533
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.12061
LBR lamin B receptor -2.10944
PEX11A peroxisomal biogenesis factor 11 alpha -2.10747
LARP7 La ribonucleoprotein domain family, member 7 -2.10298
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.10017
NELL1 NEL-like 1 (chicken) -2.08654
FDXR ferredoxin reductase -2.07422
GIN1 gypsy retrotransposon integrase 1 -2.07249
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.0551
CD58 CD58 molecule -2.04531
EXOC1 exocyst complex component 1 -2.03387
EGFL6 EGF-like-domain, multiple 6 -2.03097
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -2.02107
SIRT7 sirtuin 7 -2.01997
TK1 thymidine kinase 1, soluble -2.01698
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.00164