CRCGN015_MCF10A.WT.HP_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 99.01 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.84063
LGMN legumain 4.01478
HBA1 hemoglobin, alpha 1 3.97056
GATA2 GATA binding protein 2 3.96149
CDCA4 cell division cycle associated 4 3.842
CCL2 chemokine (C-C motif) ligand 2 3.26136
MTA2 metastasis associated 1 family, member 2 2.95603
NUTF2 nuclear transport factor 2 2.92222
CENPE centromere protein E, 312kDa 2.69869
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.6012
RBBP5 retinoblastoma binding protein 5 2.43719
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.40595
OSTF1 osteoclast stimulating factor 1 2.34295
CNRIP1 cannabinoid receptor interacting protein 1 2.32309
DCXR dicarbonyl/L-xylulose reductase 2.24655
SBNO1 strawberry notch homolog 1 (Drosophila) 2.2222
CETP cholesteryl ester transfer protein, plasma 2.12077
HBB hemoglobin, beta 2.08546
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.0808
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.07773
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.05056
COMMD8 COMM domain containing 8 2.04218
WDR76 WD repeat domain 76 2.01408
CTSB cathepsin B 2.00949
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 2.0077

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -4.59578
BASP1 brain abundant, membrane attached signal protein 1 -4.2455
SLC35F2 solute carrier family 35, member F2 -3.62877
MTERF3 mitochondrial transcription termination factor 3 -2.95678
PTPRK protein tyrosine phosphatase, receptor type, K -2.29079
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.2561
SST somatostatin -2.2528
TRIB3 tribbles pseudokinase 3 -2.18492
TLK2 tousled-like kinase 2 -2.1795
ATP11B ATPase, class VI, type 11B -2.17838
ACO2 aconitase 2, mitochondrial -2.17078
PLEKHA6 pleckstrin homology domain containing, family A member 6 -2.138
MYH9 myosin, heavy chain 9, non-muscle -2.13268
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.13097
SLAMF7 SLAM family member 7 -2.11013
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.0983
AOAH acyloxyacyl hydrolase (neutrophil) -2.08751
RTL8C retrotransposon Gag like 8C -2.08028
CAV1 caveolin 1, caveolae protein, 22kDa -2.03506
BIRC7 baculoviral IAP repeat containing 7 -2.02165