CRCGN015_MCF10A.WT.HP_24H:G22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 99.88 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

17 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:G22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 3.31814
WFS1 Wolfram syndrome 1 (wolframin) 2.81817
SNAP25 synaptosomal-associated protein, 25kDa 2.61506
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.60916
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 2.5378
ACAA1 acetyl-CoA acyltransferase 1 2.49486
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.1246
TXNL4B thioredoxin-like 4B 2.12316
SYN1 synapsin I 2.05205
IGHMBP2 immunoglobulin mu binding protein 2 2.02168
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.01783

decreased expression

Symbol Name Standardized Value
MPC2 mitochondrial pyruvate carrier 2 -3.44176
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.42066
BACE2 beta-site APP-cleaving enzyme 2 -3.16805
TRAPPC3 trafficking protein particle complex 3 -3.12939
HAT1 histone acetyltransferase 1 -3.06218
ANXA2 annexin A2 -2.19977