CRCGN015_MCF10A.WT.HP_24H:G24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 11.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:G24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.05324
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.54506
CIAO3 cytosolic iron-sulfur assembly component 3 3.44179
TRIM13 tripartite motif containing 13 3.03125
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.97246
TCEA2 transcription elongation factor A (SII), 2 2.97146
VAV3 vav 3 guanine nucleotide exchange factor 2.81355
TMEM109 transmembrane protein 109 2.71632
TBX2 T-box 2 2.6151
RGS19 regulator of G-protein signaling 19 2.48181
COMP cartilage oligomeric matrix protein 2.46181
GRWD1 glutamate-rich WD repeat containing 1 2.44639
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.28759
HPS6 Hermansky-Pudlak syndrome 6 2.28558

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.20289
TXLNA taxilin alpha -4.14629
ISOC1 isochorismatase domain containing 1 -3.7595
TRAPPC3 trafficking protein particle complex 3 -3.43044
MSN moesin -3.32531
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.12786
NPDC1 neural proliferation, differentiation and control, 1 -3.12397
MSMO1 methylsterol monooxygenase 1 -3.03645
ALDOC aldolase C, fructose-bisphosphate -2.73699
MTERF3 mitochondrial transcription termination factor 3 -2.43426
COG2 component of oligomeric golgi complex 2 -2.37942
IQGAP1 IQ motif containing GTPase activating protein 1 -2.28006
RALB v-ral simian leukemia viral oncogene homolog B -2.12088
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa -2.08249
BZW1 basic leucine zipper and W2 domains 1 -2.00784