CRCGN015_MCF10A.WT.HP_24H:H01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 101.47 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

285 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 6.45135
TXNRD1 thioredoxin reductase 1 4.71949
CCDC92 coiled-coil domain containing 92 4.51737
HBA1 hemoglobin, alpha 1 4.38012
PRAF2 PRA1 domain family, member 2 4.33248
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.3168
GLRX glutaredoxin (thioltransferase) 4.10001
STXBP1 syntaxin binding protein 1 3.83407
PYCR1 pyrroline-5-carboxylate reductase 1 3.78714
GFPT1 glutamine--fructose-6-phosphate transaminase 1 3.7043
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.68462
TCTN1 tectonic family member 1 3.61681
TRIB3 tribbles pseudokinase 3 3.41072
CEP57 centrosomal protein 57kDa 3.38983
GARS1 glycyl-tRNA synthetase 1 3.34359
TWF2 twinfilin actin binding protein 2 3.2774
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.22099
CEMIP2 cell migration inducing hyaluronidase 2 3.18836
DUSP4 dual specificity phosphatase 4 3.16811
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.1269
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.9946
INSIG1 insulin induced gene 1 2.97593
LGMN legumain 2.95977
SPAG4 sperm associated antigen 4 2.95085
TM9SF3 transmembrane 9 superfamily member 3 2.9161
ACAA1 acetyl-CoA acyltransferase 1 2.87823
S100A4 S100 calcium binding protein A4 2.87265
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.8292
DUSP6 dual specificity phosphatase 6 2.80758
PHGDH phosphoglycerate dehydrogenase 2.80233
ZCCHC24 zinc finger, CCHC domain containing 24 2.80173
GOLGB1 golgin B1 2.78964
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.73572
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.71594
VSIG2 V-set and immunoglobulin domain containing 2 2.69427
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.65899
TARS1 threonyl-tRNA synthetase 1 2.65747
TRIB1 tribbles pseudokinase 1 2.65041
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.63165
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.62142
XPOT exportin, tRNA 2.61281
SQSTM1 sequestosome 1 2.58965
BAD BCL2-associated agonist of cell death 2.56869
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.53041
COPZ1 coatomer protein complex, subunit zeta 1 2.48154
RRAGA Ras-related GTP binding A 2.47772
AARS1 alanyl-tRNA synthetase 1 2.46939
CSNK1E casein kinase 1, epsilon 2.44135
HDLBP high density lipoprotein binding protein 2.43622
RAB5B RAB5B, member RAS oncogene family 2.42079
MACROD1 MACRO domain containing 1 2.39213
METRN meteorin, glial cell differentiation regulator 2.39165
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.38486
TPCN1 two pore segment channel 1 2.37349
INTS3 integrator complex subunit 3 2.34185
VAT1 vesicle amine transport 1 2.33635
IER3 immediate early response 3 2.33432
BAMBI BMP and activin membrane-bound inhibitor 2.32629
ATXN2 ataxin 2 2.32557
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.32518
RAB21 RAB21, member RAS oncogene family 2.28804
LRP10 low density lipoprotein receptor-related protein 10 2.27496
RTN3 reticulon 3 2.27339
CKAP4 cytoskeleton-associated protein 4 2.25663
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.25112
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.22363
NUCB2 nucleobindin 2 2.21414
G0S2 G0/G1 switch 2 2.2108
CARS1 cysteinyl-tRNA synthetase 1 2.16261
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.15923
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.15192
GOLGA3 golgin A3 2.14297
FAM50A family with sequence similarity 50, member A 2.14174
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 2.13996
DUSP5 dual specificity phosphatase 5 2.13403
PSAT1 phosphoserine aminotransferase 1 2.12473
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.11049
ANXA5 annexin A5 2.10689
AFTPH aftiphilin 2.10012
RABAC1 Rab acceptor 1 (prenylated) 2.09245
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.08595
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 2.08543
SKIC2 SKI2 subunit of superkiller complex 2.0817
WDR19 WD repeat domain 19 2.08002
CREB3L2 cAMP responsive element binding protein 3-like 2 2.07368
NCOA3 nuclear receptor coactivator 3 2.07343
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.07281
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.05746
CHIC2 cysteine-rich hydrophobic domain 2 2.04519
WDR13 WD repeat domain 13 2.0447
ZFC3H1 zinc finger, C3H1-type containing 2.03081
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.02847
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 2.0272
FHL2 four and a half LIM domains 2 2.02098
BBOF1 basal body orientation factor 1 2.01954
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.01871
ACADVL acyl-CoA dehydrogenase, very long chain 2.01112
HOXA10 homeobox A10 2.00564
CIRBP cold inducible RNA binding protein 2.00401
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.00359

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -5.64326
CDC45 cell division cycle 45 -4.64048
DCK deoxycytidine kinase -4.63429
ADRB2 adrenoceptor beta 2, surface -3.99769
GINS3 GINS complex subunit 3 (Psf3 homolog) -3.88704
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.87352
PSRC1 proline/serine-rich coiled-coil 1 -3.79374
CCDC86 coiled-coil domain containing 86 -3.64034
TXNDC9 thioredoxin domain containing 9 -3.55372
BIRC5 baculoviral IAP repeat containing 5 -3.5207
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.43313
STMN1 stathmin 1 -3.42353
CCNB2 cyclin B2 -3.42107
CDK1 cyclin-dependent kinase 1 -3.34513
UBE2C ubiquitin-conjugating enzyme E2C -3.31409
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.16654
CBR3 carbonyl reductase 3 -3.14089
PLK1 polo-like kinase 1 -3.1349
PLSCR1 phospholipid scramblase 1 -3.05519
NUSAP1 nucleolar and spindle associated protein 1 -3.05176
SESN1 sestrin 1 -3.03177
CCNA2 cyclin A2 -2.96054
NUP85 nucleoporin 85kDa -2.95372
ERCC6L excision repair cross-complementation group 6-like -2.90467
LMAN2L lectin, mannose-binding 2-like -2.892
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.83937
CDCA8 cell division cycle associated 8 -2.82158
KIF4A kinesin family member 4A -2.81294
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.79839
ZDHHC6 zinc finger, DHHC-type containing 6 -2.77733
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.76925
CCNB1 cyclin B1 -2.75527
CDCA3 cell division cycle associated 3 -2.74861
NCAPG2 non-SMC condensin II complex, subunit G2 -2.74485
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.7259
RFC2 replication factor C (activator 1) 2, 40kDa -2.72536
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.71751
RFC3 replication factor C (activator 1) 3, 38kDa -2.69955
RBL1 retinoblastoma-like 1 -2.68677
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.68502
THUMPD2 THUMP domain containing 2 -2.67141
LMNB1 lamin B1 -2.6663
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.65738
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.6503
SRP9 signal recognition particle 9kDa -2.64331
SPC25 SPC25, NDC80 kinetochore complex component -2.63623
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.63436
SMNDC1 survival motor neuron domain containing 1 -2.63013
NELL1 NEL-like 1 (chicken) -2.62189
TPGS1 tubulin polyglutamylase complex subunit 1 -2.60751
BID BH3 interacting domain death agonist -2.60355
EXO1 exonuclease 1 -2.57836
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.55037
NEK2 NIMA-related kinase 2 -2.54378
DSN1 DSN1, MIS12 kinetochore complex component -2.53408
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.52896
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.52383
LINS1 lines homolog 1 -2.52188
HJURP Holliday junction recognition protein -2.51062
NUP88 nucleoporin 88kDa -2.50994
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.50853
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.50421
PCNA proliferating cell nuclear antigen -2.50232
ZNF26 zinc finger protein 26 -2.4856
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.48412
OIP5 Opa interacting protein 5 -2.47961
TUBB6 tubulin, beta 6 class V -2.46957
PRR15L proline rich 15-like -2.46908
TRAIP TRAF interacting protein -2.4426
ZNF274 zinc finger protein 274 -2.43287
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -2.43116
FAM200C family with sequence similarity 200 member C -2.43065
MCM6 minichromosome maintenance complex component 6 -2.42458
NCS1 neuronal calcium sensor 1 -2.41007
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -2.4055
ATG5 autophagy related 5 -2.39747
ASF1B anti-silencing function 1B histone chaperone -2.37279
PARP2 poly (ADP-ribose) polymerase 2 -2.37078
SRSF2 serine/arginine-rich splicing factor 2 -2.36626
CDK4 cyclin-dependent kinase 4 -2.36595
AURKA aurora kinase A -2.36201
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.36135
SNRPE small nuclear ribonucleoprotein polypeptide E -2.36106
LIPT1 lipoyltransferase 1 -2.3559
NCAPH non-SMC condensin I complex, subunit H -2.35235
GEMIN2 gem (nuclear organelle) associated protein 2 -2.35109
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.34889
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.34822
CDC25C cell division cycle 25C -2.34437
C1QBP complement component 1, q subcomponent binding protein -2.34376
NOTCH1 notch 1 -2.34062
UBIAD1 UbiA prenyltransferase domain containing 1 -2.33341
BRCA1 breast cancer 1, early onset -2.31927
IVL involucrin -2.30617
VANGL1 VANGL planar cell polarity protein 1 -2.30137
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.29616
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.28975
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.28717
DUOX1 dual oxidase 1 -2.27139
FOXM1 forkhead box M1 -2.27044
MYO19 myosin XIX -2.26481
PGAM4 phosphoglycerate mutase family member 4 -2.26305
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.26205
MCM3 minichromosome maintenance complex component 3 -2.25382
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -2.2499
KIF18B kinesin family member 18B -2.2404
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.23283
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.22852
SCYL3 SCY1-like 3 (S. cerevisiae) -2.21949
MRPL39 mitochondrial ribosomal protein L39 -2.21139
PSMC3IP PSMC3 interacting protein -2.20797
AK8 adenylate kinase 8 -2.20782
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.20305
RPA3 replication protein A3, 14kDa -2.20221
TUBGCP5 tubulin, gamma complex associated protein 5 -2.20215
DEPDC1 DEP domain containing 1 -2.19368
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.18665
RPE ribulose-5-phosphate-3-epimerase -2.18507
TMEM11 transmembrane protein 11 -2.1839
CDC7 cell division cycle 7 -2.18288
NEMP1 nuclear envelope integral membrane protein 1 -2.18161
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.18108
PRMT7 protein arginine methyltransferase 7 -2.17421
NSUN3 NOP2/Sun domain family, member 3 -2.1742
TMEM177 transmembrane protein 177 -2.16717
TUBGCP4 tubulin, gamma complex associated protein 4 -2.15867
SHCBP1 SHC SH2-domain binding protein 1 -2.1479
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.14184
HOMER3 homer scaffolding protein 3 -2.13903
TROAP trophinin associated protein -2.13801
CENPX centromere protein X -2.13643
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.13585
ABI3BP ABI family, member 3 (NESH) binding protein -2.13478
HMGB1 high mobility group box 1 -2.13477
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.13176
DNASE1L3 deoxyribonuclease I-like 3 -2.1254
TREM1 triggering receptor expressed on myeloid cells 1 -2.11906
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.11829
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.1144
LHX2 LIM homeobox 2 -2.10842
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.1074
TEX15 testis expressed 15 -2.10627
DCLRE1B DNA cross-link repair 1B -2.10486
KIF11 kinesin family member 11 -2.10223
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.1002
CCNF cyclin F -2.09979
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.09774
STAB2 stabilin 2 -2.09704
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.09271
GFI1 growth factor independent 1 transcription repressor -2.09248
KIFC1 kinesin family member C1 -2.09054
BORA bora, aurora kinase A activator -2.08564
CPAP centrosome assembly and centriole elongation protein -2.08169
USP1 ubiquitin specific peptidase 1 -2.07766
CDC23 cell division cycle 23 -2.0772
TPX2 TPX2, microtubule-associated -2.07077
EXOSC9 exosome component 9 -2.06637
XPO4 exportin 4 -2.06591
SV2B synaptic vesicle glycoprotein 2B -2.06304
ZNF529 zinc finger protein 529 -2.0628
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.06105
SMYD2 SET and MYND domain containing 2 -2.06067
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.06048
STAB1 stabilin 1 -2.05999
TOP2A topoisomerase (DNA) II alpha 170kDa -2.05892
RMI1 RecQ mediated genome instability 1 -2.05649
MCM5 minichromosome maintenance complex component 5 -2.05532
KNTC1 kinetochore associated 1 -2.05419
POLR1F RNA polymerase I subunit F -2.05041
KIF15 kinesin family member 15 -2.04839
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.04692
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.03324
RAD51AP1 RAD51 associated protein 1 -2.03007
ARHGAP15 Rho GTPase activating protein 15 -2.02967
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.02832
ADI1 acireductone dioxygenase 1 -2.02665
TFCP2L1 transcription factor CP2-like 1 -2.02429
WDR76 WD repeat domain 76 -2.02301
PIMREG PICALM interacting mitotic regulator -2.01788
GPR171 G protein-coupled receptor 171 -2.01318
IFRD2 interferon-related developmental regulator 2 -2.01102
MRPL15 mitochondrial ribosomal protein L15 -2.00817
UBXN8 UBX domain protein 8 -2.00557
MED7 mediator complex subunit 7 -2.00477
CD81 CD81 molecule -2.00275