CRCGN015_MCF10A.WT.HP_24H:H04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 99.96 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.66049
HMGA2 high mobility group AT-hook 2 3.31746
SYNGAP1 synaptic Ras GTPase activating protein 1 3.22088
BLMH bleomycin hydrolase 2.9708
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.88246
PDIA5 protein disulfide isomerase family A, member 5 2.82232
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.81773
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.78891
WIF1 WNT inhibitory factor 1 2.72068
AGR2 anterior gradient 2 2.66071
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.56757
STN1 STN1 subunit of CST complex 2.5507
PRKCH protein kinase C, eta 2.45443
GLRX glutaredoxin (thioltransferase) 2.38294
CBR3 carbonyl reductase 3 2.3464
PNKP polynucleotide kinase 3'-phosphatase 2.32425
TIAM1 T-cell lymphoma invasion and metastasis 1 2.31721
DTD1 D-tyrosyl-tRNA deacylase 1 2.2637
TTC28 tetratricopeptide repeat domain 28 2.20104
USP6NL USP6 N-terminal like 2.18503
ZMIZ1 zinc finger, MIZ-type containing 1 2.17089
KIF14 kinesin family member 14 2.1484
GARS1 glycyl-tRNA synthetase 1 2.11371
CHIC2 cysteine-rich hydrophobic domain 2 2.10338
NUCB2 nucleobindin 2 2.09188
PTTG1 pituitary tumor-transforming 1 2.0885
NT5E 5'-nucleotidase, ecto (CD73) 2.04624
TPD52L2 tumor protein D52-like 2 2.03906
EGR1 early growth response 1 2.03869
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.0156
B4GAT1 beta-1,4-glucuronyltransferase 1 2.00232

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -3.36339
TES testin LIM domain protein -3.20896
GADD45B growth arrest and DNA-damage-inducible, beta -3.06171
PCCB propionyl CoA carboxylase, beta polypeptide -3.02965
YME1L1 YME1-like 1 ATPase -3.0216
STIMATE STIM activating enhancer -2.98774
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.95452
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.87024
S100A8 S100 calcium binding protein A8 -2.83537
HAT1 histone acetyltransferase 1 -2.82847
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.75056
PRR15L proline rich 15-like -2.62072
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.59375
SH3D19 SH3 domain containing 19 -2.59278
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.53658
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.49607
SOAT2 sterol O-acyltransferase 2 -2.45593
LYPLA1 lysophospholipase I -2.35181
SNX15 sorting nexin 15 -2.34357
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.33572
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.30016
FAIM Fas apoptotic inhibitory molecule -2.26779
SORBS3 sorbin and SH3 domain containing 3 -2.26199
ORC4 origin recognition complex, subunit 4 -2.2247
SPHK2 sphingosine kinase 2 -2.22468
MAIP1 matrix AAA peptidase interacting protein 1 -2.21179
LMBR1 limb development membrane protein 1 -2.2025
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.19184
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.19043
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.19008
IRF8 interferon regulatory factor 8 -2.18523
GADD45G growth arrest and DNA-damage-inducible, gamma -2.12588
GTPBP8 GTP-binding protein 8 (putative) -2.09439
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.0847
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -2.07779
PLPBP pyridoxal phosphate binding protein -2.06485
LCAT lecithin-cholesterol acyltransferase -2.06475
MRPL15 mitochondrial ribosomal protein L15 -2.06097
PMM2 phosphomannomutase 2 -2.05913
RIOK3 RIO kinase 3 -2.04417
HSPB1 heat shock 27kDa protein 1 -2.04014
TFEB transcription factor EB -2.01977