CRCGN015_MCF10A.WT.HP_24H:H06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMBA 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.85584
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.79241
IGHMBP2 immunoglobulin mu binding protein 2 3.67172
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.17643
PKN1 protein kinase N1 2.85643
BRD2 bromodomain containing 2 2.82801
SPA17 sperm autoantigenic protein 17 2.79815
AAMDC adipogenesis associated, Mth938 domain containing 2.76548
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.7617
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.70555
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.69672
RPP38 ribonuclease P/MRP 38kDa subunit 2.58557
GARRE1 granule associated Rac and RHOG effector 1 2.49354
SNAP25 synaptosomal-associated protein, 25kDa 2.44335
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.43078
TXNL4B thioredoxin-like 4B 2.41542
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.39723
TWSG1 twisted gastrulation BMP signaling modulator 1 2.36866
MNS1 meiosis-specific nuclear structural 1 2.36327
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.36036
DEAF1 DEAF1 transcription factor 2.34555
SATB1 SATB homeobox 1 2.33629
THAP12 THAP domain containing 12 2.26811
TMEM231 transmembrane protein 231 2.25975
TTC12 tetratricopeptide repeat domain 12 2.23732
UVRAG UV radiation resistance associated 2.23488
SNW1 SNW domain containing 1 2.19714
CHD8 chromodomain helicase DNA binding protein 8 2.19187
RESF1 retroelement silencing factor 1 2.18251
DDR1 discoidin domain receptor tyrosine kinase 1 2.1792
PGAP2 post-GPI attachment to proteins 2 2.15606
PRRC2A proline-rich coiled-coil 2A 2.15209
NAV3 neuron navigator 3 2.14614
SF3A3 splicing factor 3a, subunit 3, 60kDa 2.09242
ELP4 elongator acetyltransferase complex subunit 4 2.0712
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.06603
FOXJ1 forkhead box J1 2.04099
PLAAT4 phospholipase A and acyltransferase 4 2.04012
AGK acylglycerol kinase 2.03435
ZNF195 zinc finger protein 195 2.03349
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.03164
KDM7A lysine (K)-specific demethylase 7A 2.02993
RRBP1 ribosome binding protein 1 2.00761

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -5.51641
DYNLT3 dynein, light chain, Tctex-type 3 -5.46876
ACOT9 acyl-CoA thioesterase 9 -5.29438
MRPS16 mitochondrial ribosomal protein S16 -5.11682
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.94081
PGAM4 phosphoglycerate mutase family member 4 -4.75364
COG7 component of oligomeric golgi complex 7 -3.73547
PMM2 phosphomannomutase 2 -3.45676
ANXA2 annexin A2 -3.38227
GHITM growth hormone inducible transmembrane protein -3.37091
MSMO1 methylsterol monooxygenase 1 -3.29634
CHMP4B charged multivesicular body protein 4B -3.24146
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -3.22361
HPS6 Hermansky-Pudlak syndrome 6 -3.19569
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -3.13426
RGS2 regulator of G-protein signaling 2 -2.88901
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.87917
AVPI1 arginine vasopressin-induced 1 -2.7838
OSTM1 osteopetrosis associated transmembrane protein 1 -2.77303
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.69222
SEC24C SEC24 family member C -2.65155
MVP major vault protein -2.59514
RAB32 RAB32, member RAS oncogene family -2.54995
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.48366
NTAN1 N-terminal asparagine amidase -2.47636
TMCC1 transmembrane and coiled-coil domain family 1 -2.44291
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.43617
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.39462
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.37895
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.37889
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.37178
PRDX4 peroxiredoxin 4 -2.35706
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.35407
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.34891
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -2.31752
CASD1 CAS1 domain containing 1 -2.25137
FBXW4 F-box and WD repeat domain containing 4 -2.24296
PPP4C protein phosphatase 4, catalytic subunit -2.23678
PADI3 peptidyl arginine deiminase, type III -2.2052
HIRIP3 HIRA interacting protein 3 -2.19596
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.17353
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.17141
RPS29 ribosomal protein S29 -2.14322
MYO9A myosin IXA -2.13387
ZNF500 zinc finger protein 500 -2.10885
RPS12 ribosomal protein S12 -2.10828
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.10722
MPHOSPH8 M-phase phosphoprotein 8 -2.08744
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.07951
ACKR3 atypical chemokine receptor 3 -2.07155
VAMP5 vesicle-associated membrane protein 5 -2.07151
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.07024
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.06994
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.06302
NABP2 nucleic acid binding protein 2 -2.0467
PARN poly(A)-specific ribonuclease -2.03201
MMP13 matrix metallopeptidase 13 -2.02628
MBL2 mannose-binding lectin (protein C) 2, soluble -2.02128
MBNL3 muscleblind-like splicing regulator 3 -2.01368
WHRN whirlin -2.0116
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -2.01114
HSF2BP heat shock transcription factor 2 binding protein -2.00845
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.00701