CRCGN015_MCF10A.WT.HP_24H:H14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl methacrylate 32.81 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 3.48578
SCRN1 secernin 1 3.41536
EPHB2 EPH receptor B2 3.19039
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.00602
FBXO11 F-box protein 11 2.60696
CENPE centromere protein E, 312kDa 2.59765
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.55956
ACOD1 aconitate decarboxylase 1 2.34805
PIH1D1 PIH1 domain containing 1 2.31394
SCCPDH saccharopine dehydrogenase (putative) 2.2792
AUNIP aurora kinase A and ninein interacting protein 2.19321
BACE2 beta-site APP-cleaving enzyme 2 2.11548
SETD6 SET domain containing 6 2.07749
PLAGL1 pleiomorphic adenoma gene-like 1 2.07295
TRH thyrotropin-releasing hormone 2.06201
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.0413
PEX11A peroxisomal biogenesis factor 11 alpha 2.02993
WRN Werner syndrome, RecQ helicase-like 2.01559
PDE3B phosphodiesterase 3B, cGMP-inhibited 2.0056
TSPAN4 tetraspanin 4 2.00286

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -3.43605
CTNND1 catenin (cadherin-associated protein), delta 1 -3.35718
COG2 component of oligomeric golgi complex 2 -3.35672
NGRN neugrin, neurite outgrowth associated -3.24795
GDF15 growth differentiation factor 15 -3.16357
TENT4A terminal nucleotidyltransferase 4A -2.89622
GTF2B general transcription factor IIB -2.85972
TLK2 tousled-like kinase 2 -2.74903
NUSAP1 nucleolar and spindle associated protein 1 -2.68689
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.66034
CLTB clathrin, light chain B -2.61649
FASTKD5 FAST kinase domains 5 -2.60051
ARID4B AT rich interactive domain 4B (RBP1-like) -2.27394
GOLT1A golgi transport 1A -2.26961
ZBTB5 zinc finger and BTB domain containing 5 -2.13553
PRR15L proline rich 15-like -2.12607
STAP2 signal transducing adaptor family member 2 -2.08305
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.05976
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.04733
ULK1 unc-51 like autophagy activating kinase 1 -2.03862
INSIG1 insulin induced gene 1 -2.0267