CRCGN015_MCF10A.WT.HP_24H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 99.45 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
VGLL4 vestigial-like family member 4 5.31498
HBA1 hemoglobin, alpha 1 3.6444
EAPP E2F-associated phosphoprotein 3.59509
SSBP2 single-stranded DNA binding protein 2 3.50032
SYNE2 spectrin repeat containing, nuclear envelope 2 3.44059
TGFB3 transforming growth factor, beta 3 2.82489
KDM5D lysine (K)-specific demethylase 5D 2.81399
SATB1 SATB homeobox 1 2.77118
ABHD6 abhydrolase domain containing 6 2.72098
AGR2 anterior gradient 2 2.33793
ACLY ATP citrate lyase 2.32752
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.32601
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.30949
RPL39L ribosomal protein L39-like 2.26719
BLMH bleomycin hydrolase 2.06069
FAN1 FANCD2/FANCI-associated nuclease 1 2.02994
TBPL1 TBP-like 1 2.00002

decreased expression

Symbol Name Standardized Value
SCYL3 SCY1-like 3 (S. cerevisiae) -4.37384
ANXA2 annexin A2 -3.28403
BID BH3 interacting domain death agonist -3.12571
ENOPH1 enolase-phosphatase 1 -3.04613
COG7 component of oligomeric golgi complex 7 -3.02395
RNF167 ring finger protein 167 -2.99964
GDF15 growth differentiation factor 15 -2.9883
CANT1 calcium activated nucleotidase 1 -2.96209
TEX10 testis expressed 10 -2.90792
CREG1 cellular repressor of E1A-stimulated genes 1 -2.47261
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.32183
FBXO21 F-box protein 21 -2.07635
FNDC11 fibronectin type III domain containing 11 -2.01923