CRCGN015_MCF10A.WT.HP_24H:H17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 33.15 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AXIN1 axin 1 4.39599
KLHL21 kelch-like family member 21 4.11556
EPHB2 EPH receptor B2 4.10206
FCHO1 FCH domain only 1 3.92221
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 3.09266
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.93411
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.88111
PKN1 protein kinase N1 2.76982
MALT1 MALT1 paracaspase 2.71596
WIF1 WNT inhibitory factor 1 2.63078
FGGY FGGY carbohydrate kinase domain containing 2.5623
MAP2K5 mitogen-activated protein kinase kinase 5 2.40931
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.38891
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.30411
GAB2 GRB2-associated binding protein 2 2.28086
TRIM68 tripartite motif containing 68 2.24521
BLMH bleomycin hydrolase 2.22681
RPL35 ribosomal protein L35 2.22049
SLC75A1 solute carrier family 75 member 1 2.19652
ZNF322 zinc finger protein 322 2.19006
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.18137
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 2.13234
RBMX RNA binding motif protein, X-linked 2.07061
SETD3 SET domain containing 3 2.05357
RPL6 ribosomal protein L6 2.03946

decreased expression

Symbol Name Standardized Value
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.74472
YME1L1 YME1-like 1 ATPase -4.44172
HMG20B high mobility group 20B -4.36296
MRPS16 mitochondrial ribosomal protein S16 -4.31495
CCNB1 cyclin B1 -4.12985
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -3.81187
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.69557
NGRN neugrin, neurite outgrowth associated -3.2437
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.79091
SEC24C SEC24 family member C -2.77087
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.74265
PMM2 phosphomannomutase 2 -2.55266
BASP1 brain abundant, membrane attached signal protein 1 -2.36178
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.35333
TRIB3 tribbles pseudokinase 3 -2.27293
SLC16A6 solute carrier family 16, member 6 -2.2552
PVRIG poliovirus receptor related immunoglobulin domain containing -2.23994
PHACTR1 phosphatase and actin regulator 1 -2.18943
AVPI1 arginine vasopressin-induced 1 -2.09111
PTPRK protein tyrosine phosphatase, receptor type, K -2.06788
SLC45A2 solute carrier family 45, member 2 -2.06143
TXNDC15 thioredoxin domain containing 15 -2.02962
GNLY granulysin -2.00055