CRCGN015_MCF10A.WT.HP_24H:H18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 11.05 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

21 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.20061
TBPL1 TBP-like 1 4.85866
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.53793
E2F2 E2F transcription factor 2 4.51993
SSBP2 single-stranded DNA binding protein 2 4.11582
MSRA methionine sulfoxide reductase A 3.4542
PDIA5 protein disulfide isomerase family A, member 5 2.74387
CYCS cytochrome c, somatic 2.09579
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.05168

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -4.67768
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -4.47613
BASP1 brain abundant, membrane attached signal protein 1 -3.20057
RAI14 retinoic acid induced 14 -2.90819
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.63894
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.59487
TENT4A terminal nucleotidyltransferase 4A -2.57701
ATP11B ATPase, class VI, type 11B -2.45388
ARID4B AT rich interactive domain 4B (RBP1-like) -2.28782
FAIM Fas apoptotic inhibitory molecule -2.13247
EXOSC4 exosome component 4 -2.06847
RASL11B RAS-like, family 11, member B -2.06517