CRCGN015_MCF10A.WT.HP_24H:H20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estradiol 34.78 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.70943
TBPL1 TBP-like 1 3.55076
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.47723
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.00891
SMIM40 small integral membrane protein 40 2.73105
RIC8A RIC8 guanine nucleotide exchange factor A 2.70106
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.63799
PLEK2 pleckstrin 2 2.58908
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.56491
SREK1IP1 SREK1-interacting protein 1 2.50163
UTRN utrophin 2.45665
FBXO11 F-box protein 11 2.40045
MILR1 mast cell immunoglobulin-like receptor 1 2.34198
PKN1 protein kinase N1 2.3054
NES nestin 2.29426
UFD1 ubiquitin recognition factor in ER associated degradation 1 2.26834
TPSG1 tryptase gamma 1 2.26715
VPS26C VPS26 endosomal protein sorting factor C 2.23534
PLPBP pyridoxal phosphate binding protein 2.20109
PKD2L1 polycystic kidney disease 2-like 1 2.14728
TMEM230 transmembrane protein 230 2.14206
BAK1 BCL2-antagonist/killer 1 2.13196
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 2.0993
PDE8B phosphodiesterase 8B 2.09026
POC1B-GALNT4 POC1B-GALNT4 readthrough 2.08266
SRPRA SRP receptor subunit alpha 2.07315
TRAPPC11 trafficking protein particle complex 11 2.0719
FGD6 FYVE, RhoGEF and PH domain containing 6 2.06891
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 2.06839
HOXA4 homeobox A4 2.06681
OCRL oculocerebrorenal syndrome of Lowe 2.05611
CCL24 chemokine (C-C motif) ligand 24 2.05228
RASA2 RAS p21 protein activator 2 2.04658
TMPRSS5 transmembrane protease, serine 5 2.02895
RBBP9 retinoblastoma binding protein 9 2.02742
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 2.01463
UFSP2 UFM1-specific peptidase 2 2.00757
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.00396

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -4.83377
PGAM4 phosphoglycerate mutase family member 4 -4.42561
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.31207
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.63338
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.20176
MCM3 minichromosome maintenance complex component 3 -2.70753
ARID4B AT rich interactive domain 4B (RBP1-like) -2.51417
TGFBR3 transforming growth factor, beta receptor III -2.41035
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.38285
GDF15 growth differentiation factor 15 -2.31273
TIMP1 TIMP metallopeptidase inhibitor 1 -2.26534
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.24543
RRAGA Ras-related GTP binding A -2.20265
LOXL1 lysyl oxidase-like 1 -2.14899
PFKP phosphofructokinase, platelet -2.12282
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.11836
TSPYL4 TSPY-like 4 -2.10795
COPS7A COP9 signalosome subunit 7A -2.1072
ZBED1 zinc finger, BED-type containing 1 -2.0876
NEMF nuclear export mediator factor -2.07415
HEATR1 HEAT repeat containing 1 -2.0711
RLIM ring finger protein, LIM domain interacting -2.03552
CREG1 cellular repressor of E1A-stimulated genes 1 -2.03467
KLHDC4 kelch domain containing 4 -2.0339
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.00371
MAIP1 matrix AAA peptidase interacting protein 1 -2.00256