CRCGN015_MCF10A.WT.HP_24H:H21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estradiol 11.59 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

18 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.86237
CXCR4 chemokine (C-X-C motif) receptor 4 3.19177
DENND2D DENN/MADD domain containing 2D 2.67536
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.38987
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.20521
BLMH bleomycin hydrolase 2.02079
CENPE centromere protein E, 312kDa 2.01981

decreased expression

Symbol Name Standardized Value
TES testin LIM domain protein -3.18959
SCYL3 SCY1-like 3 (S. cerevisiae) -3.15039
HAT1 histone acetyltransferase 1 -3.08969
KIF20A kinesin family member 20A -2.91992
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.8322
BASP1 brain abundant, membrane attached signal protein 1 -2.75814
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.66462
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.3316
PRCP prolylcarboxypeptidase (angiotensinase C) -2.22713
DNAL4 dynein, axonemal, light chain 4 -2.20575
YME1L1 YME1-like 1 ATPase -2.07527