CRCGN015_MCF10A.WT.HP_24H:H22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description CH-223191 100.87 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:H22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.19406
AARS1 alanyl-tRNA synthetase 1 4.75827
PRR7 proline rich 7 (synaptic) 4.36696
CARS1 cysteinyl-tRNA synthetase 1 4.22613
IGFBP3 insulin-like growth factor binding protein 3 4.21629
GARS1 glycyl-tRNA synthetase 1 4.17517
GRB10 growth factor receptor-bound protein 10 4.16347
PYCR1 pyrroline-5-carboxylate reductase 1 4.06971
CXCL2 chemokine (C-X-C motif) ligand 2 4.03415
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 4.03278
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.74933
TRIB3 tribbles pseudokinase 3 3.67045
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.48011
CCP110 centriolar coiled coil protein 110kDa 3.46649
PSAT1 phosphoserine aminotransferase 1 3.31949
TWF2 twinfilin actin binding protein 2 3.22694
ADGRE5 adhesion G protein-coupled receptor E5 3.20411
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.96735
HMOX1 heme oxygenase 1 2.88465
YARS1 tyrosyl-tRNA synthetase 1 2.74642
PXMP2 peroxisomal membrane protein 2, 22kDa 2.68847
LOC102724560 cystathionine beta-synthase 2.68088
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.62423
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.62178
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.61542
CXCL3 chemokine (C-X-C motif) ligand 3 2.57298
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.57206
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.57181
PHGDH phosphoglycerate dehydrogenase 2.54948
ACTMAP actin maturation protease 2.45336
TNIP1 TNFAIP3 interacting protein 1 2.43354
MARS1 methionyl-tRNA synthetase 1 2.42452
TBXA2R thromboxane A2 receptor 2.41348
TRIB1 tribbles pseudokinase 1 2.34341
KLC3 kinesin light chain 3 2.29453
HMGA2 high mobility group AT-hook 2 2.27706
INHBE inhibin, beta E 2.15678
VSIG2 V-set and immunoglobulin domain containing 2 2.15126
DUSP4 dual specificity phosphatase 4 2.1458
ANO10 anoctamin 10 2.11989
PYGB phosphorylase, glycogen; brain 2.10491
GOLGA3 golgin A3 2.10435
KCTD13 potassium channel tetramerization domain containing 13 2.0856
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.08211
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.06253
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.0369
FBXO46 F-box protein 46 2.03163
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.03104
SLC38A2 solute carrier family 38, member 2 2.0309
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.01191

decreased expression

Symbol Name Standardized Value
ALDOC aldolase C, fructose-bisphosphate -4.91431
S100A4 S100 calcium binding protein A4 -4.57078
CD81 CD81 molecule -4.43016
HAT1 histone acetyltransferase 1 -3.98528
YME1L1 YME1-like 1 ATPase -3.6229
UFM1 ubiquitin-fold modifier 1 -3.58873
CD320 CD320 molecule -3.54324
MSMO1 methylsterol monooxygenase 1 -3.35062
MCM3 minichromosome maintenance complex component 3 -3.13607
HOXA5 homeobox A5 -3.0702
SKP1 S-phase kinase-associated protein 1 -3.01926
ZDHHC6 zinc finger, DHHC-type containing 6 -2.67301
EIF5 eukaryotic translation initiation factor 5 -2.63449
TSPAN3 tetraspanin 3 -2.56534
CRYZ crystallin, zeta (quinone reductase) -2.54689
C1GALT1C1 C1GALT1-specific chaperone 1 -2.5358
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.48001
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.47248
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.47223
PGRMC1 progesterone receptor membrane component 1 -2.47104
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.42368
PRR15L proline rich 15-like -2.41124
ADI1 acireductone dioxygenase 1 -2.32539
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.31879
LAGE3 L antigen family, member 3 -2.28616
GTF2A2 general transcription factor IIA, 2, 12kDa -2.24845
SNX2 sorting nexin 2 -2.23833
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.22749
CBR3 carbonyl reductase 3 -2.19343
HEATR1 HEAT repeat containing 1 -2.18348
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.15846
MTREX Mtr4 exosome RNA helicase -2.14885
FBXO3 F-box protein 3 -2.13434
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.12518
UBL5 ubiquitin-like 5 -2.11739
INTS3 integrator complex subunit 3 -2.1112
ATG3 autophagy related 3 -2.10451
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 -2.09958
CETN2 centrin, EF-hand protein, 2 -2.09085
MEIS1 Meis homeobox 1 -2.07769
BAG1 BCL2-associated athanogene -2.07399
RNF11 ring finger protein 11 -2.06107
PNRC2 proline-rich nuclear receptor coactivator 2 -2.05306
PSIP1 PC4 and SFRS1 interacting protein 1 -2.03973
SLC38A6 solute carrier family 38, member 6 -2.0385
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.03279
CAB39 calcium binding protein 39 -2.03176