CRCGN015_MCF10A.WT.HP_24H:I06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monoethylhexylphthalate 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 5.51255
LYN LYN proto-oncogene, Src family tyrosine kinase 5.39891
RPL39L ribosomal protein L39-like 3.91358
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.78376
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.63639
WFS1 Wolfram syndrome 1 (wolframin) 3.3679
TBX2 T-box 2 3.33869
CCNF cyclin F 3.25696
CXCR4 chemokine (C-X-C motif) receptor 4 3.12336
KCTD5 potassium channel tetramerization domain containing 5 3.05283
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.3689
DNAAF2 dynein, axonemal, assembly factor 2 2.35354
SGPP1 sphingosine-1-phosphate phosphatase 1 2.33197
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.27455
HTD2 hydroxyacyl-thioester dehydratase type 2 2.18005
TP53RK TP53 regulating kinase 2.14181
WDR77 WD repeat domain 77 2.13962
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.13051
FTSJ3 FtsJ homolog 3 (E. coli) 2.09236
ADIPOR1 adiponectin receptor 1 2.08083
MSRA methionine sulfoxide reductase A 2.07973
TGFBR1 transforming growth factor, beta receptor 1 2.04095
SASH1 SAM and SH3 domain containing 1 2.02517
GDE1 glycerophosphodiester phosphodiesterase 1 2.01569
COX6C cytochrome c oxidase subunit VIc 2.00691

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.49193
PCNA proliferating cell nuclear antigen -5.0
SLC25A46 solute carrier family 25, member 46 -4.47837
PCCB propionyl CoA carboxylase, beta polypeptide -4.37851
PARP2 poly (ADP-ribose) polymerase 2 -4.29676
THAP11 THAP domain containing 11 -3.88436
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.31096
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.09839
DCK deoxycytidine kinase -3.00429
PANK2 pantothenate kinase 2 -3.00382
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.84932
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.76882
METTL17 methyltransferase like 17 -2.7451
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.65494
GOLGA3 golgin A3 -2.52942
ZC3H4 zinc finger CCCH-type containing 4 -2.51904
BCL10 B-cell CLL/lymphoma 10 -2.43271
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.32691
CORO1A coronin, actin binding protein, 1A -2.31714
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.30841
CD247 CD247 molecule -2.29507
DDRGK1 DDRGK domain containing 1 -2.28076
MKKS McKusick-Kaufman syndrome -2.24019
CYTL1 cytokine-like 1 -2.23652
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -2.23574
FN1 fibronectin 1 -2.19863
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -2.16179
SNX5 sorting nexin 5 -2.15335
ADIPOQ adiponectin, C1Q and collagen domain containing -2.14162
RALGDS ral guanine nucleotide dissociation stimulator -2.14151
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.1378
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.13264
SUN2 Sad1 and UNC84 domain containing 2 -2.12189
GLTP glycolipid transfer protein -2.12123
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -2.11741
ATRN attractin -2.11465
TULP4 tubby like protein 4 -2.10335
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.09816
ITGB1BP1 integrin beta 1 binding protein 1 -2.08323
PEX26 peroxisomal biogenesis factor 26 -2.07803
ACIN1 apoptotic chromatin condensation inducer 1 -2.07553
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.05158
NXT1 nuclear transport factor 2-like export factor 1 -2.03939
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.03244
MSL2 male-specific lethal 2 homolog (Drosophila) -2.03203
BBS1 Bardet-Biedl syndrome 1 -2.02502
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.01068
LEP leptin -2.00361