CRCGN015_MCF10A.WT.HP_24H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 100.46 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 4.2527
IDE insulin-degrading enzyme 3.72544
SPAG4 sperm associated antigen 4 3.71324
COQ8A coenzyme Q8A 3.69191
ADGRE5 adhesion G protein-coupled receptor E5 3.52676
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.43433
DENND2D DENN/MADD domain containing 2D 3.07414
GATA2 GATA binding protein 2 2.96686
E2F2 E2F transcription factor 2 2.91513
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.83423
HBA1 hemoglobin, alpha 1 2.79792
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.75426
EGR1 early growth response 1 2.70373
SNAP25 synaptosomal-associated protein, 25kDa 2.66752
WIF1 WNT inhibitory factor 1 2.6567
PNKP polynucleotide kinase 3'-phosphatase 2.6265
HMGA2 high mobility group AT-hook 2 2.61656
EPS8 epidermal growth factor receptor pathway substrate 8 2.44929
COL4A1 collagen, type IV, alpha 1 2.40077
MINDY1 MINDY lysine 48 deubiquitinase 1 2.30256
NT5E 5'-nucleotidase, ecto (CD73) 2.28212
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.20848
KYAT1 kynurenine aminotransferase 1 2.17773
KLHL7 kelch-like family member 7 2.17478
SYNGAP1 synaptic Ras GTPase activating protein 1 2.15784
NLRP4 NLR family, pyrin domain containing 4 2.15542
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.1488
BMAL2 basic helix-loop-helix ARNT like 2 2.11355
DUSP6 dual specificity phosphatase 6 2.09086
NR1D1 nuclear receptor subfamily 1, group D, member 1 2.08221
NUP62CL nucleoporin 62kDa C-terminal like 2.0469
KLHDC2 kelch domain containing 2 2.03927
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.03899
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.00578

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -5.18329
SMNDC1 survival motor neuron domain containing 1 -5.03177
FAIM Fas apoptotic inhibitory molecule -4.14261
ATF5 activating transcription factor 5 -3.76383
BASP1 brain abundant, membrane attached signal protein 1 -3.54598
HSPA8 heat shock 70kDa protein 8 -3.26772
TRAPPC3 trafficking protein particle complex 3 -3.0027
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.98901
EIF5 eukaryotic translation initiation factor 5 -2.96161
CANT1 calcium activated nucleotidase 1 -2.93531
JMJD6 jumonji domain containing 6 -2.89312
FAM13B family with sequence similarity 13, member B -2.84857
PRR15L proline rich 15-like -2.70458
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.69875
ZMYM4 zinc finger, MYM-type 4 -2.63852
SNIP1 Smad nuclear interacting protein 1 -2.50771
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.41082
ADRB2 adrenoceptor beta 2, surface -2.40939
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.40083
NOTCH1 notch 1 -2.29932
SRSF3 serine/arginine-rich splicing factor 3 -2.27368
ZNF14 zinc finger protein 14 -2.25241
NLRP2B NLR family pyrin domain containing 2B -2.2154
SRSF2 serine/arginine-rich splicing factor 2 -2.19222
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.1881
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.17621
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.16977
ZDHHC6 zinc finger, DHHC-type containing 6 -2.15806
TMEM50A transmembrane protein 50A -2.11839
RBM22 RNA binding motif protein 22 -2.10668
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -2.1046
ZNF202 zinc finger protein 202 -2.06942
ZCCHC10 zinc finger, CCHC domain containing 10 -2.06847
DCTPP1 dCTP pyrophosphatase 1 -2.05467
FAM53C family with sequence similarity 53, member C -2.05462
BLCAP bladder cancer associated protein -2.04966
GCC1 GRIP and coiled-coil domain containing 1 -2.04598
SLC35B1 solute carrier family 35, member B1 -2.04528
SIAH1 siah E3 ubiquitin protein ligase 1 -2.03787
LSM1 LSM1, U6 small nuclear RNA associated -2.02474
MYNN myoneurin -2.02001
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.01905
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.01629
CYCS cytochrome c, somatic -2.00399