CRCGN015_MCF10A.WT.HP_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 5.86157
PPARG peroxisome proliferator-activated receptor gamma 4.28423
NRIP1 nuclear receptor interacting protein 1 4.22507
DDR1 discoidin domain receptor tyrosine kinase 1 3.78289
SPAG4 sperm associated antigen 4 3.51334
CARMIL1 capping protein regulator and myosin 1 linker 1 3.47987
CCL2 chemokine (C-C motif) ligand 2 3.35981
SNAP25 synaptosomal-associated protein, 25kDa 3.21508
HBA1 hemoglobin, alpha 1 2.53787
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.39252
HOXA4 homeobox A4 2.35434
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.1896
SCG3 secretogranin III 2.11246
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.10714
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.02439
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 2.01574
ASXL2 additional sex combs like transcriptional regulator 2 2.01523

decreased expression

Symbol Name Standardized Value
SCYL3 SCY1-like 3 (S. cerevisiae) -4.83469
LDHD lactate dehydrogenase D -3.69098
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.61169
CD81 CD81 molecule -3.5738
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.20549
FOS FBJ murine osteosarcoma viral oncogene homolog -2.92211
HEATR1 HEAT repeat containing 1 -2.77022
NT5DC2 5'-nucleotidase domain containing 2 -2.60883
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.32863
ALPK1 alpha-kinase 1 -2.3285
AGK acylglycerol kinase -2.32176
PMM2 phosphomannomutase 2 -2.31547
SLC66A2 solute carrier family 66 member 2 -2.29029
S100A8 S100 calcium binding protein A8 -2.28577
SFT2D2 SFT2 domain containing 2 -2.25478
RPA3 replication protein A3, 14kDa -2.23577
SEPHS2 selenophosphate synthetase 2 -2.20728
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.18279
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -2.15447
ERN2 endoplasmic reticulum to nucleus signaling 2 -2.14457
CASZ1 castor zinc finger 1 -2.14256
ADRB2 adrenoceptor beta 2, surface -2.10988
TSPAN5 tetraspanin 5 -2.10839
RFTN1 raftlin, lipid raft linker 1 -2.07528
GPR137B G protein-coupled receptor 137B -2.04032
MMP9 matrix metallopeptidase 9 -2.03773
DNASE1L3 deoxyribonuclease I-like 3 -2.0235