CRCGN015_MCF10A.WT.HP_24H:I12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1260 10.65 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 4.13099
SNAP25 synaptosomal-associated protein, 25kDa 3.70634
ABHD6 abhydrolase domain containing 6 3.60573
SPAG4 sperm associated antigen 4 3.59547
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.47303
AGR2 anterior gradient 2 3.45879
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.45754
MAMLD1 mastermind-like domain containing 1 3.30032
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 3.10803
CARMIL1 capping protein regulator and myosin 1 linker 1 3.04083
HOXD10 homeobox D10 3.03957
E2F2 E2F transcription factor 2 2.76848
COMP cartilage oligomeric matrix protein 2.75236
CIAO3 cytosolic iron-sulfur assembly component 3 2.73131
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.67784
CETP cholesteryl ester transfer protein, plasma 2.65085
TXNL4B thioredoxin-like 4B 2.53102
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.47956
POU4F2 POU class 4 homeobox 2 2.43547
MCRS1 microspherule protein 1 2.38541
CNRIP1 cannabinoid receptor interacting protein 1 2.35999
AMHR2 anti-Mullerian hormone receptor, type II 2.3422
MEF2C myocyte enhancer factor 2C 2.33178
ACTN2 actinin, alpha 2 2.30034
ITPKC inositol-trisphosphate 3-kinase C 2.29628
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.29174
COQ8A coenzyme Q8A 2.2702
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.25753
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.23572
NEFL neurofilament, light polypeptide 2.17794
SV2B synaptic vesicle glycoprotein 2B 2.15784
ACAA1 acetyl-CoA acyltransferase 1 2.13372
CDH18 cadherin 18, type 2 2.12988
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.12862
SNAP91 synaptosomal-associated protein, 91kDa 2.09957
FAM20B family with sequence similarity 20, member B 2.07082
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.06198
HOXD11 homeobox D11 2.03658
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.03261
HAVCR1 hepatitis A virus cellular receptor 1 2.02763
SSUH2 ssu-2 homolog (C. elegans) 2.01692
FAM171A1 family with sequence similarity 171, member A1 2.01269
PRDM8 PR domain containing 8 2.01252

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -3.95418
SCYL3 SCY1-like 3 (S. cerevisiae) -3.88525
PRPF4 pre-mRNA processing factor 4 -3.45179
TRAPPC3 trafficking protein particle complex 3 -3.39226
RNF167 ring finger protein 167 -3.35061
TUBB6 tubulin, beta 6 class V -3.29924
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.26851
COG2 component of oligomeric golgi complex 2 -3.25222
DYNLT3 dynein, light chain, Tctex-type 3 -3.21501
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.98222
GADD45B growth arrest and DNA-damage-inducible, beta -2.84074
DCK deoxycytidine kinase -2.82769
LOC122539214 Zinc finger protein LOC122539214 -2.69717
ZNF761 zinc finger protein 761 -2.67726
BID BH3 interacting domain death agonist -2.67642
BSPRY B-box and SPRY domain containing -2.61438
IRF8 interferon regulatory factor 8 -2.59337
TIMP1 TIMP metallopeptidase inhibitor 1 -2.56355
HAT1 histone acetyltransferase 1 -2.38609
SYT17 synaptotagmin XVII -2.3041
TAGLN2 transgelin 2 -2.18035
SGK1 serum/glucocorticoid regulated kinase 1 -2.0588