CRCGN015_MCF10A.WT.HP_24H:I13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 101.79 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 4.77216
SPAG4 sperm associated antigen 4 4.35175
E2F2 E2F transcription factor 2 3.82903
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.47106
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.16087
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 3.09947
TIAM1 T-cell lymphoma invasion and metastasis 1 2.8812
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.86242
PKN1 protein kinase N1 2.84547
RSF1 remodeling and spacing factor 1 2.82238
THAP12 THAP domain containing 12 2.69417
AAMDC adipogenesis associated, Mth938 domain containing 2.59726
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.54553
PDIA5 protein disulfide isomerase family A, member 5 2.26761
KCTD14 potassium channel tetramerization domain containing 14 2.24279
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 2.18694
PPARG peroxisome proliferator-activated receptor gamma 2.11471
INPP1 inositol polyphosphate-1-phosphatase 2.06487
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.05663
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.04433

decreased expression

Symbol Name Standardized Value
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -4.38675
COG7 component of oligomeric golgi complex 7 -3.69801
VDAC1 voltage-dependent anion channel 1 -3.01257
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.91547
COPS7A COP9 signalosome subunit 7A -2.82274
TENT4A terminal nucleotidyltransferase 4A -2.67062
NLRP4 NLR family, pyrin domain containing 4 -2.58757
AAMP angio-associated, migratory cell protein -2.19978
DNASE2 deoxyribonuclease II, lysosomal -2.17625
HEATR6 HEAT repeat containing 6 -2.12158
GDF15 growth differentiation factor 15 -2.09546
KATNIP katanin interacting protein -2.06625
IL10RB interleukin 10 receptor, beta -2.04256