CRCGN015_MCF10A.WT.HP_24H:I14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 33.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 6.65751
AGR2 anterior gradient 2 4.84359
KIF5C kinesin family member 5C 3.46046
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.79463
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 2.59453
RAB31 RAB31, member RAS oncogene family 2.51192
CCDC6 coiled-coil domain containing 6 2.45957
MEPCE methylphosphate capping enzyme 2.43719
TSPAN8 tetraspanin 8 2.42255
NRBF2 nuclear receptor binding factor 2 2.37368
NBPF3 neuroblastoma breakpoint family, member 3 2.36113
ZNF189 zinc finger protein 189 2.34129
EXD2 exonuclease 3'-5' domain containing 2 2.30373
CCL2 chemokine (C-C motif) ligand 2 2.20178
EXOC1 exocyst complex component 1 2.12667
DOLK dolichol kinase 2.08244
DET1 de-etiolated homolog 1 (Arabidopsis) 2.0667
EVL Enah/Vasp-like 2.06558
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.05978
CCT4 chaperonin containing TCP1, subunit 4 (delta) 2.04388
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.01974
NFIL3 nuclear factor, interleukin 3 regulated 2.01962
KARS1 lysyl-tRNA synthetase 1 2.01733

decreased expression

Symbol Name Standardized Value
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.77991
CCDC86 coiled-coil domain containing 86 -3.54706
DCK deoxycytidine kinase -3.05468
JMJD6 jumonji domain containing 6 -2.97959
CD44 CD44 molecule (Indian blood group) -2.71448
KIF14 kinesin family member 14 -2.70832
VAT1 vesicle amine transport 1 -2.56706
PGAM4 phosphoglycerate mutase family member 4 -2.54209
MXRA7 matrix-remodelling associated 7 -2.35988
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.25686
NCAPD2 non-SMC condensin I complex, subunit D2 -2.18243
IPO13 importin 13 -2.14014
TCL1A T-cell leukemia/lymphoma 1A -2.09061
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.08811
VPREB3 pre-B lymphocyte 3 -2.0727
AHDC1 AT hook, DNA binding motif, containing 1 -2.03373
CCL14 chemokine (C-C motif) ligand 14 -2.03101
CENPX centromere protein X -2.02698