CRCGN015_MCF10A.WT.HP_24H:I15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 11.31 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 4.25098
EVL Enah/Vasp-like 4.13449
COMP cartilage oligomeric matrix protein 3.88241
IGHMBP2 immunoglobulin mu binding protein 2 3.43508
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.25101
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.20322
BPHL biphenyl hydrolase-like (serine hydrolase) 3.02298
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.85529
HAVCR1 hepatitis A virus cellular receptor 1 2.71828
CRYAB crystallin, alpha B 2.40505
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.2696
MTM1 myotubularin 1 2.26179
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.19284
MNX1 motor neuron and pancreas homeobox 1 2.18333
CD33 CD33 molecule 2.15664
COL11A1 collagen, type XI, alpha 1 2.14506
VGLL4 vestigial-like family member 4 2.13983
SCRG1 stimulator of chondrogenesis 1 2.09721
IL24 interleukin 24 2.05274
ADGRE5 adhesion G protein-coupled receptor E5 2.03398
IL2RA interleukin 2 receptor, alpha 2.02412

decreased expression

Symbol Name Standardized Value
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.62521
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -4.07463
KCTD5 potassium channel tetramerization domain containing 5 -3.68784
MSN moesin -3.60818
DYNLT3 dynein, light chain, Tctex-type 3 -3.29139
ADI1 acireductone dioxygenase 1 -3.13701
CANT1 calcium activated nucleotidase 1 -2.8563
NRIP1 nuclear receptor interacting protein 1 -2.82282
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.2905
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.27091
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.15992
CD81 CD81 molecule -2.15648
BASP1 brain abundant, membrane attached signal protein 1 -2.06858
COPS7A COP9 signalosome subunit 7A -2.04262
PTPRK protein tyrosine phosphatase, receptor type, K -2.00566