CRCGN015_MCF10A.WT.HP_24H:I19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 98.88 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

119 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 8.12255
AGR2 anterior gradient 2 3.75039
NSG2 neuronal vesicle trafficking associated 2 3.71729
SNAP91 synaptosomal-associated protein, 91kDa 3.43425
GNG3 guanine nucleotide binding protein (G protein), gamma 3 3.37785
CDPF1 cysteine-rich, DPF motif domain containing 1 3.08853
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 3.08783
IGHMBP2 immunoglobulin mu binding protein 2 3.08709
STMN2 stathmin 2 3.03605
SYN1 synapsin I 3.01784
SYT1 synaptotagmin I 2.98448
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.97195
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.95602
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.93283
CARTPT CART prepropeptide 2.80136
SV2B synaptic vesicle glycoprotein 2B 2.75528
AMPH amphiphysin 2.7311
ODF1 outer dense fiber of sperm tails 1 2.70751
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.70577
CADM1 cell adhesion molecule 1 2.66776
BEX2 brain expressed X-linked 2 2.63755
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.63733
MYT1L myelin transcription factor 1-like 2.62361
RPL10L ribosomal protein L10-like 2.61235
ACTL6B actin-like 6B 2.58697
VSNL1 visinin-like 1 2.57923
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.57551
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.56187
NEFM neurofilament, medium polypeptide 2.54542
RGS7 regulator of G-protein signaling 7 2.51774
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.50832
NEFL neurofilament, light polypeptide 2.47844
KDM5D lysine (K)-specific demethylase 5D 2.43983
PDYN prodynorphin 2.43074
RUNDC3A RUN domain containing 3A 2.42957
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.42946
ADGRB3 adhesion G protein-coupled receptor B3 2.38939
SCG3 secretogranin III 2.3681
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.36252
EIF4A2 eukaryotic translation initiation factor 4A2 2.32692
USP9Y ubiquitin specific peptidase 9, Y-linked 2.31938
KIAA0513 KIAA0513 2.31571
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.30965
HTN1 histatin 1 2.29984
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.29432
LGI1 leucine-rich, glioma inactivated 1 2.29192
PCSK2 proprotein convertase subtilisin/kexin type 2 2.25974
SH3GL2 SH3-domain GRB2-like 2 2.24667
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.24365
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.24324
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.22723
TAGLN3 transgelin 3 2.2088
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.20857
ATOX1 antioxidant 1 copper chaperone 2.20727
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 2.205
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 2.20329
SEZ6L seizure related 6 homolog (mouse)-like 2.19265
PCSK1 proprotein convertase subtilisin/kexin type 1 2.19048
PYGL phosphorylase, glycogen, liver 2.17081
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.17044
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.16129
PALS2 protein associated with LIN7 2, MAGUK p55 family member 2.15646
HTN3 histatin 3 2.15298
HBA1 hemoglobin, alpha 1 2.15279
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.14806
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.14735
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.1402
GPC5 glypican 5 2.13342
SEC14L5 SEC14-like 5 (S. cerevisiae) 2.12769
ASIC2 acid sensing (proton gated) ion channel 2 2.12527
CAMTA1 calmodulin binding transcription activator 1 2.12239
LSAMP limbic system-associated membrane protein 2.11043
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.09982
IGBP1 immunoglobulin (CD79A) binding protein 1 2.08358
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.0781
SMR3B submaxillary gland androgen regulated protein 3B 2.06503
GRAMD1B GRAM domain containing 1B 2.05969
OLFM1 olfactomedin 1 2.04441
HOXA10 homeobox A10 2.04075
STIMATE STIM activating enhancer 2.0388
MYOM1 myomesin 1 2.03785
WDTC1 WD and tetratricopeptide repeats 1 2.03455
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.03226
WFS1 Wolfram syndrome 1 (wolframin) 2.03134
SYP synaptophysin 2.02544
BNC1 basonuclin 1 2.01498
RGS20 regulator of G-protein signaling 20 2.0109
PTPRN protein tyrosine phosphatase, receptor type, N 2.00543
NME4 NME/NM23 nucleoside diphosphate kinase 4 2.0048

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -4.5706
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.13586
LDHD lactate dehydrogenase D -4.04986
GOLT1B golgi transport 1B -3.96814
TES testin LIM domain protein -3.62817
NUSAP1 nucleolar and spindle associated protein 1 -3.44401
RGS2 regulator of G-protein signaling 2 -3.31496
MSN moesin -3.21832
FAIM Fas apoptotic inhibitory molecule -2.91157
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.82738
ARID4B AT rich interactive domain 4B (RBP1-like) -2.71522
RECQL RecQ helicase-like -2.61327
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.60277
CCDC86 coiled-coil domain containing 86 -2.54337
PODXL podocalyxin-like -2.31261
MTERF3 mitochondrial transcription termination factor 3 -2.28578
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.22932
ATF5 activating transcription factor 5 -2.17246
DOK7 docking protein 7 -2.15556
PSRC1 proline/serine-rich coiled-coil 1 -2.14573
DNM1 dynamin 1 -2.14281
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.13479
BRMS1L breast cancer metastasis-suppressor 1-like -2.08358
ELL3 elongation factor RNA polymerase II-like 3 -2.07352
SS18 synovial sarcoma translocation, chromosome 18 -2.05785
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.05345
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -2.02448
ANPEP alanyl (membrane) aminopeptidase -2.0232
LRRC40 leucine rich repeat containing 40 -2.01429
ELOVL1 ELOVL fatty acid elongase 1 -2.00905