CRCGN015_MCF10A.WT.HP_24H:I20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 32.96 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.80709
AMDHD2 amidohydrolase domain containing 2 4.67966
GPER1 G protein-coupled estrogen receptor 1 4.57766
CRELD2 cysteine-rich with EGF-like domains 2 3.54555
EVL Enah/Vasp-like 3.25691
ACAA1 acetyl-CoA acyltransferase 1 3.07938
CDK19 cyclin-dependent kinase 19 2.47451
SESN1 sestrin 1 2.453
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.32463
SCT secretin 2.14051
CDHR2 cadherin-related family member 2 2.11892
FBXO40 F-box protein 40 2.1039
RORB RAR-related orphan receptor B 2.08657
ECEL1 endothelin converting enzyme-like 1 2.05995
ADGRF1 adhesion G protein-coupled receptor F1 2.04967
MNMIP1 manchette microtubule inner protein 1 2.04274
AKAP4 A kinase (PRKA) anchor protein 4 2.03486
SOX30 SRY (sex determining region Y)-box 30 2.0278
OPRK1 opioid receptor, kappa 1 2.00955

decreased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 -4.75955
KIF14 kinesin family member 14 -4.4254
THAP11 THAP domain containing 11 -4.25266
DCK deoxycytidine kinase -3.60914
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.41371
ANXA2 annexin A2 -3.18073
HEATR1 HEAT repeat containing 1 -2.77092
GDF15 growth differentiation factor 15 -2.62294
CDC25B cell division cycle 25B -2.51656
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.27428
PFN1 profilin 1 -2.25337
TRAP1 TNF receptor-associated protein 1 -2.19974
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.11392
TENT2 terminal nucleotidyltransferase 2 -2.06282