CRCGN015_MCF10A.WT.HP_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 10.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

14 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 5.05704
MAMLD1 mastermind-like domain containing 1 4.877
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 4.0507
ZW10 zw10 kinetochore protein 3.09296
TBX2 T-box 2 2.7685
COMP cartilage oligomeric matrix protein 2.65515
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.5705
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.29352
METTL22 methyltransferase like 22 2.1022
TMEM186 transmembrane protein 186 2.04434

decreased expression

Symbol Name Standardized Value
VDAC1 voltage-dependent anion channel 1 -3.08123
KIF14 kinesin family member 14 -3.01764
SCYL3 SCY1-like 3 (S. cerevisiae) -2.7024
TOMM70 translocase of outer mitochondrial membrane 70 -2.34416