CRCGN015_MCF10A.WT.HP_24H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 100.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.81697
PEX11A peroxisomal biogenesis factor 11 alpha 3.76271
TBX2 T-box 2 3.41629
GPER1 G protein-coupled estrogen receptor 1 3.11353
FGFR4 fibroblast growth factor receptor 4 3.0453
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.82
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.73858
IL1B interleukin 1, beta 2.70564
ACAA1 acetyl-CoA acyltransferase 1 2.44799
RBBP5 retinoblastoma binding protein 5 2.42953
MTA2 metastasis associated 1 family, member 2 2.11148
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.04752
MDM4 MDM4, p53 regulator 2.02739
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.00272

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -5.07841
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.38859
KIF14 kinesin family member 14 -3.38968
RGS2 regulator of G-protein signaling 2 -3.21346
MRPL58 mitochondrial ribosomal protein L58 -3.07061
SUMO4 small ubiquitin-like modifier 4 -2.93486
MRPS7 mitochondrial ribosomal protein S7 -2.83839
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.61329
ATP5PD ATP synthase peripheral stalk subunit d -2.54194
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.28078
TRIT1 tRNA isopentenyltransferase 1 -2.23323
KCTD2 potassium channel tetramerization domain containing 2 -2.07477