CRCGN015_MCF10A.WT.HP_24H:I23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.67307
MSRA methionine sulfoxide reductase A 4.17321
PLEKHJ1 pleckstrin homology domain containing, family J member 1 4.03832
CRELD2 cysteine-rich with EGF-like domains 2 3.30172
TXNL4B thioredoxin-like 4B 2.76596
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.42575
IL1B interleukin 1, beta 2.42364
RNPEP arginyl aminopeptidase (aminopeptidase B) 2.28785
RGS7 regulator of G-protein signaling 7 2.24767
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.24644
AURKB aurora kinase B 2.20007
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.15333
UGP2 UDP-glucose pyrophosphorylase 2 2.15274
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.14698
FBP1 fructose-1,6-bisphosphatase 1 2.12471
MILR1 mast cell immunoglobulin-like receptor 1 2.11577
ZSCAN9 zinc finger and SCAN domain containing 9 2.1135
TGFB3 transforming growth factor, beta 3 2.11299
WDR7 WD repeat domain 7 2.0654
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 2.05704
USP2 ubiquitin specific peptidase 2 2.03525
COMP cartilage oligomeric matrix protein 2.02757
FPGS folylpolyglutamate synthase 2.01277
FDX1 ferredoxin 1 2.01043

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -9.5268
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.80318
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.61741
MSMO1 methylsterol monooxygenase 1 -4.43887
GOLT1B golgi transport 1B -4.38926
TIMP1 TIMP metallopeptidase inhibitor 1 -4.09911
MSN moesin -3.34919
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.15558
CD320 CD320 molecule -2.84694
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.81841
RPA3 replication protein A3, 14kDa -2.81351
SQSTM1 sequestosome 1 -2.78465
ETV6 ets variant 6 -2.74235
TM9SF2 transmembrane 9 superfamily member 2 -2.65843
TP53 tumor protein p53 -2.61697
NUP88 nucleoporin 88kDa -2.56194
THAP11 THAP domain containing 11 -2.52463
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.50778
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.50096
MCM3 minichromosome maintenance complex component 3 -2.43462
COG4 component of oligomeric golgi complex 4 -2.41266
SARAF store-operated calcium entry-associated regulatory factor -2.39591
HSPA1A heat shock 70kDa protein 1A -2.34226
SMIM10L1 small integral membrane protein 10 like 1 -2.22404
ERGIC2 ERGIC and golgi 2 -2.21919
WBP11 WW domain binding protein 11 -2.21221
RPL36 ribosomal protein L36 -2.19677
E2F2 E2F transcription factor 2 -2.16829
RECQL RecQ helicase-like -2.13254