CRCGN015_MCF10A.WT.HP_24H:I24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:I24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 6.10039
COMP cartilage oligomeric matrix protein 4.2692
C2CD2 C2 calcium-dependent domain containing 2 3.60889
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.2864
EVL Enah/Vasp-like 3.17758
FGFR4 fibroblast growth factor receptor 4 2.86672
AURKB aurora kinase B 2.59537
MMP2 matrix metallopeptidase 2 2.16577
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 2.14471
HYOU1 hypoxia up-regulated 1 2.10101

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -3.96744
CHMP4B charged multivesicular body protein 4B -3.70564
CCNB1 cyclin B1 -3.43718
LYPLA1 lysophospholipase I -3.0396
RNF167 ring finger protein 167 -3.03326
POU3F2 POU class 3 homeobox 2 -2.69423
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.69156
GNAS GNAS complex locus -2.66865
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -2.46686
ATP5F1E ATP synthase F1 subunit epsilon -2.28221
MCM3 minichromosome maintenance complex component 3 -2.23679
COPS7A COP9 signalosome subunit 7A -2.21195
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.20884
ARB2A ARB2 cotranscriptional regulator A -2.17331
SRFBP1 serum response factor binding protein 1 -2.14564
RPL34 ribosomal protein L34 -2.09638
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.07549
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.04829
JTB jumping translocation breakpoint -2.03555
POU4F1 POU class 4 homeobox 1 -2.02362