CRCGN015_MCF10A.WT.HP_24H:J04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl toluene 99.96 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.72354
ZW10 zw10 kinetochore protein 3.34852
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.8593
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.64717
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.55406
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.48624
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.34822
DNM2 dynamin 2 2.27538
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.26799
LAS1L LAS1-like (S. cerevisiae) 2.2533
BCL3 B-cell CLL/lymphoma 3 2.25105
ACAA1 acetyl-CoA acyltransferase 1 2.13506
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.13108
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 2.00747

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.08712
OXA1L oxidase (cytochrome c) assembly 1-like -5.03636
RGS2 regulator of G-protein signaling 2 -4.04098
CDK1 cyclin-dependent kinase 1 -3.24664
UFM1 ubiquitin-fold modifier 1 -3.14774
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.88101
DNM1L dynamin 1-like -2.72022
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.58632
TXNDC9 thioredoxin domain containing 9 -2.54028
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.3743
PLAAT2 phospholipase A and acyltransferase 2 -2.36045
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.35929
PKP2 plakophilin 2 -2.33374
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) -2.31892
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.29632
MTREX Mtr4 exosome RNA helicase -2.23123
GMPR2 guanosine monophosphate reductase 2 -2.20797
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.20701
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.0762
MED21 mediator complex subunit 21 -2.02982
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.01754
CNN1 calponin 1, basic, smooth muscle -2.01569