CRCGN015_MCF10A.WT.HP_24H:J06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl toluene 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 4.61041
PPARG peroxisome proliferator-activated receptor gamma 4.45149
KDM5D lysine (K)-specific demethylase 5D 3.73274
USP9Y ubiquitin specific peptidase 9, Y-linked 3.66598
WIF1 WNT inhibitory factor 1 3.55461
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.44883
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.37704
TIAM1 T-cell lymphoma invasion and metastasis 1 2.75072
MNS1 meiosis-specific nuclear structural 1 2.61627
TMEM243 transmembrane protein 243, mitochondrial 2.57769
TRIP13 thyroid hormone receptor interactor 13 2.56215
CDC25C cell division cycle 25C 2.55308
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.55061
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 2.51017
TTC12 tetratricopeptide repeat domain 12 2.42339
SKA1 spindle and kinetochore associated complex subunit 1 2.41573
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.31807
AKTIP AKT interacting protein 2.247
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.22631
DROSHA drosha, ribonuclease type III 2.22332
RAD51AP1 RAD51 associated protein 1 2.21406
MCRS1 microspherule protein 1 2.21158
ACTA2 actin, alpha 2, smooth muscle, aorta 2.20331
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 2.1748
SPC25 SPC25, NDC80 kinetochore complex component 2.16627
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.16498
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.1584
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.15703
KIF18A kinesin family member 18A 2.14061
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.13473
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.11397
PKN1 protein kinase N1 2.10381
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.0968
ARHGAP10 Rho GTPase activating protein 10 2.08948
SPA17 sperm autoantigenic protein 17 2.08699
NADSYN1 NAD synthetase 1 2.07317
YEATS4 YEATS domain containing 4 2.07124
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.07088
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.049
NELL2 NEL-like 2 (chicken) 2.03944
CARM1 coactivator-associated arginine methyltransferase 1 2.02184
TBK1 TANK-binding kinase 1 2.02031
OGG1 8-oxoguanine DNA glycosylase 2.01704
PDF peptide deformylase (mitochondrial) 2.00766
DEDD death effector domain containing 2.00035

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -8.41338
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -8.26293
COG2 component of oligomeric golgi complex 2 -4.4747
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -4.40199
CDC20 cell division cycle 20 -4.15497
GDF15 growth differentiation factor 15 -3.5629
HMOX2 heme oxygenase 2 -3.29545
MSN moesin -3.15603
UBA1 ubiquitin-like modifier activating enzyme 1 -3.0066
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.87651
MSMO1 methylsterol monooxygenase 1 -2.85662
PYGB phosphorylase, glycogen; brain -2.78653
UBN1 ubinuclein 1 -2.76452
ELOVL1 ELOVL fatty acid elongase 1 -2.74672
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.5089
CAPN3 calpain 3, (p94) -2.49806
TYR tyrosinase -2.49445
CCNL2 cyclin L2 -2.46722
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.4513
BCL2L13 BCL2-like 13 (apoptosis facilitator) -2.44596
PAQR4 progestin and adipoQ receptor family member IV -2.42104
MBNL3 muscleblind-like splicing regulator 3 -2.40492
GAK cyclin G associated kinase -2.38216
KDM5C lysine (K)-specific demethylase 5C -2.37314
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.36577
NPC1L1 NPC1-like 1 -2.32535
EIF2D eukaryotic translation initiation factor 2D -2.30396
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.30032
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.29435
TRIM25 tripartite motif containing 25 -2.29051
PMM2 phosphomannomutase 2 -2.2872
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.26357
HLA-A major histocompatibility complex, class I, A -2.24201
MUTYH mutY homolog -2.24162
EBLN2 endogenous Bornavirus-like nucleoprotein 2 -2.23931
ZNF263 zinc finger protein 263 -2.23905
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.22545
SZT2 seizure threshold 2 homolog (mouse) -2.22455
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.20649
PTBP1 polypyrimidine tract binding protein 1 -2.17402
CACTIN cactin, spliceosome C complex subunit -2.16586
RHOB ras homolog family member B -2.16373
TTC17 tetratricopeptide repeat domain 17 -2.14283
APOA1 apolipoprotein A-I -2.14161
LORICRIN loricrin cornified envelope precursor protein -2.12493
MAGT1 magnesium transporter 1 -2.12399
SIN3B SIN3 transcription regulator family member B -2.12222
SPRR1B small proline-rich protein 1B -2.12048
SLC39A2 solute carrier family 39 (zinc transporter), member 2 -2.11944
USP9X ubiquitin specific peptidase 9, X-linked -2.0847
APOA2 apolipoprotein A-II -2.08372
ZNF500 zinc finger protein 500 -2.08263
GNPAT glyceronephosphate O-acyltransferase -2.06794
ZC4H2 zinc finger, C4H2 domain containing -2.06437
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.05855
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 -2.05488
PRR11 proline rich 11 -2.05422
HMBOX1 homeobox containing 1 -2.04501
RAB8B RAB8B, member RAS oncogene family -2.03872
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.03727
CDIP1 cell death-inducing p53 target 1 -2.03675
SH3GL1 SH3-domain GRB2-like 1 -2.02107
TTC4 tetratricopeptide repeat domain 4 -2.02076
NOP14 NOP14 nucleolar protein -2.01746
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.01724
MARF1 meiosis regulator and mRNA stability factor 1 -2.01604
ABHD18 abhydrolase domain containing 18 -2.0154
NDEL1 nudE neurodevelopment protein 1-like 1 -2.01333
METTL22 methyltransferase like 22 -2.01032