CRCGN015_MCF10A.WT.HP_24H:J07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethinyl estradiol 99.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.11388
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.96913
ADAM10 ADAM metallopeptidase domain 10 4.90042
USP6NL USP6 N-terminal like 4.89813
HOXA5 homeobox A5 4.60194
IGHMBP2 immunoglobulin mu binding protein 2 3.99596
NRIP1 nuclear receptor interacting protein 1 3.45285
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.37746
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.12519
KDM5A lysine (K)-specific demethylase 5A 3.01653
TPD52L2 tumor protein D52-like 2 2.74078
METRN meteorin, glial cell differentiation regulator 2.73543
AGR2 anterior gradient 2 2.55448
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.37386
MINDY2 MINDY lysine 48 deubiquitinase 2 2.30528
PLSCR3 phospholipid scramblase 3 2.25902
ZBTB38 zinc finger and BTB domain containing 38 2.17359
SMAD3 SMAD family member 3 2.16005
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 2.12633
GRWD1 glutamate-rich WD repeat containing 1 2.09663
CHL1 cell adhesion molecule L1-like 2.0547
EIF6 eukaryotic translation initiation factor 6 2.01869
WDTC1 WD and tetratricopeptide repeats 1 2.00584

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.1555
TSPAN4 tetraspanin 4 -5.02868
NPDC1 neural proliferation, differentiation and control, 1 -4.88227
HAT1 histone acetyltransferase 1 -4.77904
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.48852
PARP2 poly (ADP-ribose) polymerase 2 -4.3489
NUSAP1 nucleolar and spindle associated protein 1 -4.1958
CD81 CD81 molecule -3.47988
HAUS7 HAUS augmin-like complex, subunit 7 -2.69253
CETN2 centrin, EF-hand protein, 2 -2.6814
MCM3 minichromosome maintenance complex component 3 -2.66386
CCL14 chemokine (C-C motif) ligand 14 -2.62229
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.61718
ACKR1 atypical chemokine receptor 1 (Duffy blood group) -2.5996
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -2.55864
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.55476
CRY2 cryptochrome circadian clock 2 -2.2996
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.27618
NISCH nischarin -2.25362
BCAP31 B-cell receptor-associated protein 31 -2.22416
KRT14 keratin 14, type I -2.12201
HEATR6 HEAT repeat containing 6 -2.11608
GORASP2 golgi reassembly stacking protein 2, 55kDa -2.07571
PAGE4 P antigen family, member 4 (prostate associated) -2.0698
SF3B4 splicing factor 3b, subunit 4, 49kDa -2.00806