CRCGN015_MCF10A.WT.HP_24H:J08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethinyl estradiol 33.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ICAM3 intercellular adhesion molecule 3 4.58998
HOXA5 homeobox A5 4.21705
EAPP E2F-associated phosphoprotein 4.20147
AGR2 anterior gradient 2 4.187
CNPY3 canopy FGF signaling regulator 3 3.78645
HBA1 hemoglobin, alpha 1 3.52524
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3.30878
PPARG peroxisome proliferator-activated receptor gamma 3.11747
NRIP1 nuclear receptor interacting protein 1 3.01937
VGLL4 vestigial-like family member 4 2.95632
ACAA1 acetyl-CoA acyltransferase 1 2.95098
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.88861
MBIP MAP3K12 binding inhibitory protein 1 2.78373
WIF1 WNT inhibitory factor 1 2.63125
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.61115
SYNGAP1 synaptic Ras GTPase activating protein 1 2.4919
COMP cartilage oligomeric matrix protein 2.37667
ECD ecdysoneless homolog (Drosophila) 2.34092
GRWD1 glutamate-rich WD repeat containing 1 2.33358
SCFD1 sec1 family domain containing 1 2.30271
ABHD4 abhydrolase domain containing 4 2.29758
PDIA5 protein disulfide isomerase family A, member 5 2.22751
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.17379
GET1 guided entry of tail-anchored proteins factor 1 2.11538
COQ8A coenzyme Q8A 2.07737
SLC75A1 solute carrier family 75 member 1 2.02405

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -4.91198
ETFB electron-transfer-flavoprotein, beta polypeptide -4.09875
COG2 component of oligomeric golgi complex 2 -4.02464
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.69095
CCNB2 cyclin B2 -3.60763
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.52875
BPHL biphenyl hydrolase-like (serine hydrolase) -3.44831
HAT1 histone acetyltransferase 1 -3.29035
TIMP1 TIMP metallopeptidase inhibitor 1 -3.01685
TENT4A terminal nucleotidyltransferase 4A -2.34351
SCGB2A1 secretoglobin, family 2A, member 1 -2.31569
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.3064
MBD1 methyl-CpG binding domain protein 1 -2.1939
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.17666
SOX17 SRY (sex determining region Y)-box 17 -2.17091
SCYL3 SCY1-like 3 (S. cerevisiae) -2.1432
TNNT1 troponin T type 1 (skeletal, slow) -2.13013
DYNC2I1 dynein 2 intermediate chain 1 -2.09313
STX4 syntaxin 4 -2.04064
KANSL3 KAT8 regulatory NSL complex subunit 3 -2.03249
ASRGL1 asparaginase like 1 -2.01994
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.00953
CEP72 centrosomal protein 72kDa -2.00369