CRCGN015_MCF10A.WT.HP_24H:J11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

105 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 7.78049
SNAP25 synaptosomal-associated protein, 25kDa 7.34498
FHL2 four and a half LIM domains 2 4.15944
PNKP polynucleotide kinase 3'-phosphatase 4.11201
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.7043
NRIP1 nuclear receptor interacting protein 1 3.62872
BAG3 BCL2-associated athanogene 3 3.5725
PDIA5 protein disulfide isomerase family A, member 5 3.52885
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.49583
CASP7 caspase 7, apoptosis-related cysteine peptidase 3.49406
CNRIP1 cannabinoid receptor interacting protein 1 3.44744
STMN2 stathmin 2 3.44594
SPAG4 sperm associated antigen 4 3.17729
TAC1 tachykinin, precursor 1 3.14765
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.12985
IL1B interleukin 1, beta 3.11082
HOXA4 homeobox A4 3.06668
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.96042
SYT1 synaptotagmin I 2.8514
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.73076
SMAD3 SMAD family member 3 2.71423
NSG2 neuronal vesicle trafficking associated 2 2.69842
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.69708
KLHL21 kelch-like family member 21 2.66901
NPY neuropeptide Y 2.644
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.60601
WIF1 WNT inhibitory factor 1 2.60155
CBR3 carbonyl reductase 3 2.55357
HOXA7 homeobox A7 2.53822
AGR2 anterior gradient 2 2.53404
TCEA2 transcription elongation factor A (SII), 2 2.51679
MICALL1 MICAL-like 1 2.45029
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.39196
SCG3 secretogranin III 2.35697
BAG2 BCL2-associated athanogene 2 2.34529
E2F2 E2F transcription factor 2 2.30573
INPP1 inositol polyphosphate-1-phosphatase 2.305
LBR lamin B receptor 2.27623
HMOX1 heme oxygenase 1 2.26747
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 2.25946
CXCL6 chemokine (C-X-C motif) ligand 6 2.23532
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.20134
ADGRE5 adhesion G protein-coupled receptor E5 2.19186
TAGLN3 transgelin 3 2.18853
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.16178
SCN1A sodium channel, voltage gated, type I alpha subunit 2.15929
SYN1 synapsin I 2.15132
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.1444
CDCA4 cell division cycle associated 4 2.14079
SNAP91 synaptosomal-associated protein, 91kDa 2.13801
NEFL neurofilament, light polypeptide 2.11455
CENPU centromere protein U 2.11449
TBPL1 TBP-like 1 2.11153
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.10635
CGGBP1 CGG triplet repeat binding protein 1 2.08214
PCSK1 proprotein convertase subtilisin/kexin type 1 2.0676
EYA2 EYA transcriptional coactivator and phosphatase 2 2.06356
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.06341
ACAA1 acetyl-CoA acyltransferase 1 2.06054
RAB23 RAB23, member RAS oncogene family 2.05954
CCDC59 coiled-coil domain containing 59 2.03994
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.03385
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.02448
NEFH neurofilament, heavy polypeptide 2.02192
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.01857
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.00777
POU4F1 POU class 4 homeobox 1 2.00294

decreased expression

Symbol Name Standardized Value
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -4.58301
SGK1 serum/glucocorticoid regulated kinase 1 -3.79708
S100A4 S100 calcium binding protein A4 -3.75547
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.68555
MSN moesin -3.30086
DSG2 desmoglein 2 -2.97973
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.96346
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.91997
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.90173
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.50941
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.49807
ZNF573 zinc finger protein 573 -2.44868
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.4409
EDN1 endothelin 1 -2.35288
CCNJL cyclin J-like -2.30995
MAVS mitochondrial antiviral signaling protein -2.27579
UBOX5 U-box domain containing 5 -2.2544
RAB36 RAB36, member RAS oncogene family -2.22394
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.22087
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.1907
RGS2 regulator of G-protein signaling 2 -2.1831
ZDHHC11B zinc finger, DHHC-type containing 11B -2.16727
DDRGK1 DDRGK domain containing 1 -2.1587
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -2.13381
NLRP4 NLR family, pyrin domain containing 4 -2.13369
NEO1 neogenin 1 -2.12936
BLCAP bladder cancer associated protein -2.11831
EXPH5 exophilin 5 -2.10967
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -2.10106
CYB5RL cytochrome b5 reductase-like -2.09067
ZC2HC1C zinc finger, C2HC-type containing 1C -2.07237
TZMP1 transition zone microprotein 1 -2.04605
TMC5 transmembrane channel-like 5 -2.04593
MAGEF1 melanoma antigen family F1 -2.02918
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.02587
CUTA cutA divalent cation tolerance homolog (E. coli) -2.02242
SIRPA signal-regulatory protein alpha -2.01647
TMEM230 transmembrane protein 230 -2.00789