CRCGN015_MCF10A.WT.HP_24H:J12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 11.14 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

91 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 7.55643
HBA1 hemoglobin, alpha 1 5.63676
AGR2 anterior gradient 2 4.47891
KLHL21 kelch-like family member 21 4.12886
SMAD3 SMAD family member 3 3.84054
PDIA5 protein disulfide isomerase family A, member 5 3.77847
FHL2 four and a half LIM domains 2 3.76255
MYLK myosin light chain kinase 3.76105
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.50082
NRIP1 nuclear receptor interacting protein 1 3.47443
TCEA2 transcription elongation factor A (SII), 2 3.42696
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.3492
AXIN1 axin 1 3.30244
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.20135
PRKCD protein kinase C, delta 3.15714
BAG3 BCL2-associated athanogene 3 2.89631
SNX11 sorting nexin 11 2.81715
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.72816
CBR3 carbonyl reductase 3 2.72788
RPP38 ribonuclease P/MRP 38kDa subunit 2.63155
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.62037
CENPU centromere protein U 2.53436
DSG2 desmoglein 2 2.46267
INPP1 inositol polyphosphate-1-phosphatase 2.45038
MICALL1 MICAL-like 1 2.39662
HBB hemoglobin, beta 2.39547
PFN2 profilin 2 2.31518
IL1B interleukin 1, beta 2.31444
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.29709
THAP12 THAP domain containing 12 2.24225
PLSCR1 phospholipid scramblase 1 2.23078
PRPF18 pre-mRNA processing factor 18 2.15554
TASOR2 transcription activation suppressor family member 2 2.13433
MCUR1 mitochondrial calcium uniporter regulator 1 2.12549
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.11462
HOXA4 homeobox A4 2.06953
TMEM11 transmembrane protein 11 2.02196
MRPL42 mitochondrial ribosomal protein L42 2.0114

decreased expression

Symbol Name Standardized Value
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -6.51062
MSMO1 methylsterol monooxygenase 1 -4.34064
COG7 component of oligomeric golgi complex 7 -4.00308
TES testin LIM domain protein -3.8686
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.85236
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.83021
S100A4 S100 calcium binding protein A4 -3.42692
NUP85 nucleoporin 85kDa -3.15747
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.69711
NT5DC2 5'-nucleotidase domain containing 2 -2.58977
TENT4A terminal nucleotidyltransferase 4A -2.58814
RGS2 regulator of G-protein signaling 2 -2.55684
ASGR2 asialoglycoprotein receptor 2 -2.42296
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.39876
SGK1 serum/glucocorticoid regulated kinase 1 -2.38136
TIMP1 TIMP metallopeptidase inhibitor 1 -2.33047
ZNF331 zinc finger protein 331 -2.31148
NSUN5 NOP2/Sun domain family, member 5 -2.30831
BID BH3 interacting domain death agonist -2.30805
INHBB inhibin, beta B -2.28387
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.28275
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.28135
TENM1 teneurin transmembrane protein 1 -2.27737
HLA-E major histocompatibility complex, class I, E -2.26543
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.24676
ACAD10 acyl-CoA dehydrogenase family, member 10 -2.19389
KAT2A K(lysine) acetyltransferase 2A -2.19261
ZNF544 zinc finger protein 544 -2.19023
ZNF559-ZNF177 ZNF559-ZNF177 readthrough -2.18185
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.17977
KDM8 lysine (K)-specific demethylase 8 -2.17489
SCN9A sodium channel, voltage gated, type IX alpha subunit -2.17216
ANKZF1 ankyrin repeat and zinc finger domain containing 1 -2.15984
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -2.15002
ASGR1 asialoglycoprotein receptor 1 -2.14493
ZNF175 zinc finger protein 175 -2.13164
HLA-F major histocompatibility complex, class I, F -2.12489
RARS1 arginyl-tRNA synthetase 1 -2.1246
LMBR1L limb development membrane protein 1-like -2.12282
ADAMTSL4 ADAMTS-like 4 -2.10476
MRPS7 mitochondrial ribosomal protein S7 -2.09144
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.08607
ZNF573 zinc finger protein 573 -2.07541
TMEM184C transmembrane protein 184C -2.06724
TMEM94 transmembrane protein 94 -2.06213
PTPRK protein tyrosine phosphatase, receptor type, K -2.05986
TG thyroglobulin -2.05946
EXT1 exostosin glycosyltransferase 1 -2.04065
WDR19 WD repeat domain 19 -2.03189
BSN bassoon presynaptic cytomatrix protein -2.01414
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 -2.01232
PLPPR4 phospholipid phosphatase related 4 -2.01215
WBP2 WW domain binding protein 2 -2.00939