CRCGN015_MCF10A.WT.HP_24H:J18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(1-naphthyl)ethylenediamine.2hcl 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:J18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EAPP E2F-associated phosphoprotein 5.25445
KLHL21 kelch-like family member 21 4.89739
VGLL4 vestigial-like family member 4 4.42526
EVL Enah/Vasp-like 3.80497
WIF1 WNT inhibitory factor 1 3.68626
GRB10 growth factor receptor-bound protein 10 3.6594
TBX2 T-box 2 3.26301
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.12269
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.92803
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.79087
ADRB2 adrenoceptor beta 2, surface 2.71523
SPTSSA serine palmitoyltransferase, small subunit A 2.59245
SYNGAP1 synaptic Ras GTPase activating protein 1 2.48708
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.27158
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.1234
PKN1 protein kinase N1 2.12084
SRP54 signal recognition particle 54kDa 2.11759
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.09122
FKBP3 FK506 binding protein 3, 25kDa 2.05266
DENND2D DENN/MADD domain containing 2D 2.04822
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.02885
TXNL4B thioredoxin-like 4B 2.00357

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.56423
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.87663
GDF15 growth differentiation factor 15 -4.12345
SCYL3 SCY1-like 3 (S. cerevisiae) -2.71117
ZSCAN26 zinc finger and SCAN domain containing 26 -2.46616
TMEM267 transmembrane protein 267 -2.41813
ZNF287 zinc finger protein 287 -2.35629
PUM3 pumilio RNA binding family member 3 -2.31307
IL9 interleukin 9 -2.27148
PRKX protein kinase, X-linked -2.2526
CNN3 calponin 3, acidic -2.23403
AFAP1 actin filament associated protein 1 -2.22728
MTERF4 mitochondrial transcription termination factor 4 -2.21791
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.20299
SNAP91 synaptosomal-associated protein, 91kDa -2.19017
ZNF280A zinc finger protein 280A -2.17764
ACSBG1 acyl-CoA synthetase bubblegum family member 1 -2.1632
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.14594
MSANTD3-TMEFF1 MSANTD3-TMEFF1 readthrough -2.13512
SNCAIP synuclein, alpha interacting protein -2.12226
IL3 interleukin 3 -2.11242
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.10228
TTYH1 tweety family member 1 -2.09681
FGF7 fibroblast growth factor 7 -2.07176
GYG2 glycogenin 2 -2.0692
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.05321
INSM1 insulinoma-associated 1 -2.04708
IL2 interleukin 2 -2.04553
ENDOU endonuclease, polyU-specific -2.03778
NUP155 nucleoporin 155kDa -2.02502
GSTCD glutathione S-transferase, C-terminal domain containing -2.02386
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.01719
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.00422