CRCGN015_MCF10A.WT.HP_24H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description simazine 102.07 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 6.52917
SNAP25 synaptosomal-associated protein, 25kDa 5.41999
TLR4 toll-like receptor 4 4.3274
UBQLN2 ubiquilin 2 3.82848
WIF1 WNT inhibitory factor 1 3.59312
ZW10 zw10 kinetochore protein 3.28389
VGLL4 vestigial-like family member 4 3.0378
AGR2 anterior gradient 2 2.96825
STMN2 stathmin 2 2.83759
CBARP CACN subunit beta associated regulatory protein 2.82708
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.79769
PRH1 proline-rich protein HaeIII subfamily 1 2.75699
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.73703
NSG2 neuronal vesicle trafficking associated 2 2.73512
NEFM neurofilament, medium polypeptide 2.71355
HOXA7 homeobox A7 2.70203
BPHL biphenyl hydrolase-like (serine hydrolase) 2.68886
LIAS lipoic acid synthetase 2.68202
ATXN7L1 ataxin 7-like 1 2.66883
RBKS ribokinase 2.53537
ACAA1 acetyl-CoA acyltransferase 1 2.47508
SSTR1 somatostatin receptor 1 2.4555
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.40632
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.40527
ZIC1 Zic family member 1 2.39711
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.39094
ETNPPL ethanolamine-phosphate phospho-lyase 2.38374
MATN4 matrilin 4 2.37516
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.3728
NEFL neurofilament, light polypeptide 2.3671
RGS9BP regulator of G protein signaling 9 binding protein 2.36025
SCT secretin 2.35671
GSDMD gasdermin D 2.32435
SORBS1 sorbin and SH3 domain containing 1 2.32292
FES FES proto-oncogene, tyrosine kinase 2.31355
COMP cartilage oligomeric matrix protein 2.30537
TBL3 transducin (beta)-like 3 2.28081
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.27144
LTC4S leukotriene C4 synthase 2.25756
FBXL15 F-box and leucine-rich repeat protein 15 2.24935
MRPL30 mitochondrial ribosomal protein L30 2.24781
SCG3 secretogranin III 2.24589
MAPK4 mitogen-activated protein kinase 4 2.24519
DGKH diacylglycerol kinase, eta 2.24393
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.23403
TTC38 tetratricopeptide repeat domain 38 2.2095
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.20453
HPCA hippocalcin 2.20192
NAP1L3 nucleosome assembly protein 1-like 3 2.19696
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.16018
FAM174C family with sequence similarity 174 member C 2.15865
SSTR5 somatostatin receptor 5 2.14441
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.13406
HPR haptoglobin-related protein 2.13121
NDRG4 NDRG family member 4 2.12256
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.11268
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 2.11143
SYN1 synapsin I 2.10347
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 2.08717
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.08407
ASTN2 astrotactin 2 2.07813
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 2.07561
PDIA5 protein disulfide isomerase family A, member 5 2.06325
HIKESHI heat shock protein nuclear import factor hikeshi 2.05465
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.04731
LCN1 lipocalin 1 2.04286
P3H3 prolyl 3-hydroxylase 3 2.04286
OSGEP O-sialoglycoprotein endopeptidase 2.03763
OGDHL oxoglutarate dehydrogenase-like 2.03227
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.03055
FGF17 fibroblast growth factor 17 2.02625
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 2.01072

decreased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 -5.17521
GDF15 growth differentiation factor 15 -4.3418
VAT1 vesicle amine transport 1 -3.9103
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.78543
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.50264
GNAS GNAS complex locus -3.46513
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.94963
YME1L1 YME1-like 1 ATPase -2.89104
TRIB3 tribbles pseudokinase 3 -2.78842
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.51969
TGFBI transforming growth factor, beta-induced, 68kDa -2.37809
THSD1 thrombospondin, type I, domain containing 1 -2.32531
STXBP2 syntaxin binding protein 2 -2.30475
ADORA2B adenosine A2b receptor -2.27406
CHIT1 chitinase 1 (chitotriosidase) -2.24537
ISL1 ISL LIM homeobox 1 -2.23983
ESRP1 epithelial splicing regulatory protein 1 -2.134
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides -2.11603
NIPAL2 NIPA-like domain containing 2 -2.08474
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.06452
FOXK2 forkhead box K2 -2.05191
PMP22 peripheral myelin protein 22 -2.02394
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.01471