CRCGN015_MCF10A.WT.HP_24H:K01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenol 99.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 4.74591
SNAP25 synaptosomal-associated protein, 25kDa 4.63892
RPP38 ribonuclease P/MRP 38kDa subunit 4.55732
STAP2 signal transducing adaptor family member 2 4.42579
KDM5D lysine (K)-specific demethylase 5D 4.15928
VGLL4 vestigial-like family member 4 4.02431
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.74939
CHEK1 checkpoint kinase 1 3.64433
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.35827
COMP cartilage oligomeric matrix protein 3.33361
AGR2 anterior gradient 2 3.16352
HLA-DRA major histocompatibility complex, class II, DR alpha 2.83713
KIN Kin17 DNA and RNA binding protein 2.75966
NLGN4Y neuroligin 4, Y-linked 2.66924
RIOK2 RIO kinase 2 2.57605
SV2C synaptic vesicle glycoprotein 2C 2.53771
USP9Y ubiquitin specific peptidase 9, Y-linked 2.51191
DROSHA drosha, ribonuclease type III 2.47352
CRTC3 CREB regulated transcription coactivator 3 2.41735
UBB ubiquitin B 2.41252
MINDY3 MINDY lysine 48 deubiquitinase 3 2.38724
ZNF280A zinc finger protein 280A 2.37346
AZIN2 antizyme inhibitor 2 2.36095
IL5 interleukin 5 2.35643
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.34782
NANS N-acetylneuraminic acid synthase 2.30317
ZFY zinc finger protein, Y-linked 2.27731
NELFA negative elongation factor complex member A 2.27563
SCRG1 stimulator of chondrogenesis 1 2.27504
LRRN3 leucine rich repeat neuronal 3 2.27027
CDC123 cell division cycle 123 2.2616
FER fer (fps/fes related) tyrosine kinase 2.24809
PTTG1 pituitary tumor-transforming 1 2.24171
IL2RA interleukin 2 receptor, alpha 2.21206
TRH thyrotropin-releasing hormone 2.21001
TBXA2R thromboxane A2 receptor 2.20362
IL24 interleukin 24 2.19876
MCM10 minichromosome maintenance complex component 10 2.19498
EIF3E eukaryotic translation initiation factor 3, subunit E 2.1832
FBLN5 fibulin 5 2.17435
OGFRL1 opioid growth factor receptor-like 1 2.14178
SOCS5 suppressor of cytokine signaling 5 2.1395
MAGEC1 melanoma antigen family C1 2.13936
STMN2 stathmin 2 2.13395
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.13042
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.11609
DNAAF2 dynein, axonemal, assembly factor 2 2.10795
PDIA5 protein disulfide isomerase family A, member 5 2.10662
SMC6 structural maintenance of chromosomes 6 2.10353
TARS1 threonyl-tRNA synthetase 1 2.08788
UGP2 UDP-glucose pyrophosphorylase 2 2.07744
TATDN2 TatD DNase domain containing 2 2.07601
BMS1 BMS1 ribosome biogenesis factor 2.07531
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.07117
VRK1 vaccinia related kinase 1 2.05634
NSG2 neuronal vesicle trafficking associated 2 2.03817
IL13RA2 interleukin 13 receptor, alpha 2 2.02709
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.01858
RPH3A rabphilin 3A 2.01819
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 2.01082
PRPF18 pre-mRNA processing factor 18 2.00918
ADGRL3 adhesion G protein-coupled receptor L3 2.00072

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -4.83119
ELAC2 elaC ribonuclease Z 2 -4.4845
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.37503
TIMP1 TIMP metallopeptidase inhibitor 1 -4.13002
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.07413
MSMO1 methylsterol monooxygenase 1 -3.94374
CTNND1 catenin (cadherin-associated protein), delta 1 -3.89401
SLC35F2 solute carrier family 35, member F2 -3.8492
CA2 carbonic anhydrase II -3.2924
SMC1A structural maintenance of chromosomes 1A -3.25037
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.20875
KDM5C lysine (K)-specific demethylase 5C -2.84815
PNPLA4 patatin-like phospholipase domain containing 4 -2.68969
RPA3 replication protein A3, 14kDa -2.5549
VMP1 vacuole membrane protein 1 -2.42433
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.41152
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.38404
SGK1 serum/glucocorticoid regulated kinase 1 -2.36533
PUDP pseudouridine 5'-phosphatase -2.33247
HCK HCK proto-oncogene, Src family tyrosine kinase -2.26416
FAM174B family with sequence similarity 174, member B -2.25308
S100A8 S100 calcium binding protein A8 -2.23176
FASN fatty acid synthase -2.18159
ELL3 elongation factor RNA polymerase II-like 3 -2.16252
NMRK2 nicotinamide riboside kinase 2 -2.15224
GPR137B G protein-coupled receptor 137B -2.14548
LOC122539214 Zinc finger protein LOC122539214 -2.11957
USP9X ubiquitin specific peptidase 9, X-linked -2.09195
VCAM1 vascular cell adhesion molecule 1 -2.08938
CD1C CD1c molecule -2.08333
TAC3 tachykinin 3 -2.07443
NFE2L1 nuclear factor, erythroid 2-like 1 -2.07106
CD207 CD207 molecule, langerin -2.03417
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.01886
ZNF263 zinc finger protein 263 -2.01438
BCAS4 breast carcinoma amplified sequence 4 -2.01361