CRCGN015_MCF10A.WT.HP_24H:K02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenol 33.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.94562
CCDC92 coiled-coil domain containing 92 4.71659
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.99893
HBA1 hemoglobin, alpha 1 3.88182
BZW2 basic leucine zipper and W2 domains 2 3.65848
CENPE centromere protein E, 312kDa 2.58498
RPP38 ribonuclease P/MRP 38kDa subunit 2.46965
SETD1B SET domain containing 1B 2.46745
FZD7 frizzled class receptor 7 2.36514
WIF1 WNT inhibitory factor 1 2.33327
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.25513
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.18573
PAGR1 PAXIP1 associated glutamate-rich protein 1 2.14742
ARHGAP17 Rho GTPase activating protein 17 2.10603
ATAD2 ATPase family, AAA domain containing 2 2.06601
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.01126
ANKRD10 ankyrin repeat domain 10 2.00709

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.59125
TIMP1 TIMP metallopeptidase inhibitor 1 -4.82072
COG2 component of oligomeric golgi complex 2 -4.74412
PCNA proliferating cell nuclear antigen -4.22446
CYCS cytochrome c, somatic -4.07531
HAT1 histone acetyltransferase 1 -4.04192
MRPS2 mitochondrial ribosomal protein S2 -4.01297
PPP1R26 protein phosphatase 1, regulatory subunit 26 -3.11557
PAEP progestagen-associated endometrial protein -3.09014
CDC45 cell division cycle 45 -3.04818
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.95822
GDF15 growth differentiation factor 15 -2.84778
MSN moesin -2.81664
COQ4 coenzyme Q4 -2.75777
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.65963
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -2.59662
VILL villin-like -2.56616
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.55828
AGTR1 angiotensin II receptor, type 1 -2.4849
COXFA4 cytochrome c oxidase associated subunit FA4 -2.46959
BPHL biphenyl hydrolase-like (serine hydrolase) -2.41692
PLAAT4 phospholipase A and acyltransferase 4 -2.38413
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.32179
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -2.31191
CBX3 chromobox homolog 3 -2.26875
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.21539
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.20924
OTOR otoraplin -2.16036
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.14432
GGCT gamma-glutamylcyclotransferase -2.14295
PBLD phenazine biosynthesis-like protein domain containing -2.13885
LRRN2 leucine rich repeat neuronal 2 -2.12692
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.12505
LOC122539214 Zinc finger protein LOC122539214 -2.11601
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.10022
GJD2 gap junction protein, delta 2, 36kDa -2.09513
CCDC57 coiled-coil domain containing 57 -2.08896
TSPAN15 tetraspanin 15 -2.07089
NMRK1 nicotinamide riboside kinase 1 -2.06487
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.03028
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 -2.02932
THNSL2 threonine synthase-like 2 (S. cerevisiae) -2.01535
SOX12 SRY (sex determining region Y)-box 12 -2.0148
ANAPC2 anaphase promoting complex subunit 2 -2.01348