CRCGN015_MCF10A.WT.HP_24H:K04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethoxane 98.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.01422
STIMATE STIM activating enhancer 4.68262
CERK ceramide kinase 3.01549
TBX2 T-box 2 2.89712
ZMIZ1 zinc finger, MIZ-type containing 1 2.79305
CENPE centromere protein E, 312kDa 2.72994
SATB1 SATB homeobox 1 2.71307
PDIA5 protein disulfide isomerase family A, member 5 2.65294
ZNF589 zinc finger protein 589 2.57605
AGR2 anterior gradient 2 2.39125
CCNA1 cyclin A1 2.25376
TMEM248 transmembrane protein 248 2.13452
BABAM2 BRISC and BRCA1 A complex member 2 2.10456

decreased expression

Symbol Name Standardized Value
WASHC5 WASH complex subunit 5 -5.13385
DYNLT3 dynein, light chain, Tctex-type 3 -5.05751
GDF15 growth differentiation factor 15 -5.01427
S100A8 S100 calcium binding protein A8 -4.78189
ISOC1 isochorismatase domain containing 1 -4.78052
TM9SF3 transmembrane 9 superfamily member 3 -4.47377
OXA1L oxidase (cytochrome c) assembly 1-like -4.39308
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.82365
SLC35F2 solute carrier family 35, member F2 -3.78557
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.6151
RGS2 regulator of G-protein signaling 2 -3.61359
SCYL3 SCY1-like 3 (S. cerevisiae) -3.43211
BID BH3 interacting domain death agonist -3.36007
TIMP1 TIMP metallopeptidase inhibitor 1 -2.84029
TUBA4A tubulin, alpha 4a -2.51468
TMEM184C transmembrane protein 184C -2.51034
ATF5 activating transcription factor 5 -2.47871
NABP2 nucleic acid binding protein 2 -2.45843
SGK1 serum/glucocorticoid regulated kinase 1 -2.40837
TKT transketolase -2.35251
TRIB3 tribbles pseudokinase 3 -2.23543
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B -2.22362
MAGT1 magnesium transporter 1 -2.21963
GLTP glycolipid transfer protein -2.21797
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.17711
HINFP histone H4 transcription factor -2.1627
SYNGR3 synaptogyrin 3 -2.15148
REXO2 RNA exonuclease 2 -2.10567
LORICRIN loricrin cornified envelope precursor protein -2.0982
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.094
TPGS1 tubulin polyglutamylase complex subunit 1 -2.07227
C8A complement component 8, alpha polypeptide -2.05302
RND1 Rho family GTPase 1 -2.02389
HPS6 Hermansky-Pudlak syndrome 6 -2.0127
HSF2BP heat shock transcription factor 2 binding protein -2.0096