CRCGN015_MCF10A.WT.HP_24H:K05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethoxane 32.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

262 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.23393
COMP cartilage oligomeric matrix protein 5.23167
AXIN1 axin 1 4.39785
DIPK1A divergent protein kinase domain 1A 4.37325
COL11A1 collagen, type XI, alpha 1 3.56434
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.5284
FCHO1 FCH domain only 1 3.32393
SOCS2 suppressor of cytokine signaling 2 3.31048
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.275
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 3.24326
TEAD3 TEA domain family member 3 3.03769
SMIM40 small integral membrane protein 40 3.02214
IGHMBP2 immunoglobulin mu binding protein 2 2.91712
GRB7 growth factor receptor-bound protein 7 2.88116
LAMA5 laminin, alpha 5 2.86682
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.85686
GAS6 growth arrest-specific 6 2.8044
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.79596
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.77832
TMEM160 transmembrane protein 160 2.77021
TENT4A terminal nucleotidyltransferase 4A 2.7632
BRD7 bromodomain containing 7 2.69211
TRIM39-RPP21 TRIM39-RPP21 readthrough 2.69081
AEBP1 AE binding protein 1 2.68931
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.61353
PODXL2 podocalyxin-like 2 2.60123
GSDMB gasdermin B 2.58928
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.58111
LIMD2 LIM domain containing 2 2.57618
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 2.55833
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.54147
THBS3 thrombospondin 3 2.49799
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.49037
PPARD peroxisome proliferator-activated receptor delta 2.48777
MUC2 mucin 2, oligomeric mucus/gel-forming 2.48657
ADGRB2 adhesion G protein-coupled receptor B2 2.48533
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.46253
EDN1 endothelin 1 2.44521
DCAF15 DDB1 and CUL4 associated factor 15 2.43923
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.43916
PRR7 proline rich 7 (synaptic) 2.43257
PDE9A phosphodiesterase 9A 2.4259
ACE angiotensin I converting enzyme 2.42363
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.42
CLCNKB chloride channel, voltage-sensitive Kb 2.41849
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.41051
ERCC2 excision repair cross-complementation group 2 2.40974
PRKCG protein kinase C, gamma 2.39979
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.38424
MMP23B matrix metallopeptidase 23B 2.35626
BGLAP bone gamma-carboxyglutamate (gla) protein 2.33992
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.33689
EMILIN1 elastin microfibril interfacer 1 2.33189
IPO13 importin 13 2.32203
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.31012
AMH anti-Mullerian hormone 2.29978
EGF epidermal growth factor 2.29406
MICALL2 MICAL-like 2 2.29125
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.29031
IRF3 interferon regulatory factor 3 2.28526
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.28267
HOXD11 homeobox D11 2.26424
USP2 ubiquitin specific peptidase 2 2.2565
ISYNA1 inositol-3-phosphate synthase 1 2.25074
GPR132 G protein-coupled receptor 132 2.25004
IRX4 iroquois homeobox 4 2.2484
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.2482
SCRT1 scratch family zinc finger 1 2.24134
ZC3H12A zinc finger CCCH-type containing 12A 2.23172
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.23131
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 2.23051
CDK10 cyclin-dependent kinase 10 2.22791
CNN1 calponin 1, basic, smooth muscle 2.22062
GHR growth hormone receptor 2.2156
TERT telomerase reverse transcriptase 2.20692
TM4SF20 transmembrane 4 L six family member 20 2.19999
LOC102724023 ES1 protein homolog, mitochondrial 2.19499
CLDN16 claudin 16 2.18881
BYSL bystin-like 2.18822
WWC1 WW and C2 domain containing 1 2.18604
GRK1 G protein-coupled receptor kinase 1 2.18375
CAPN10 calpain 10 2.1837
EPYC epiphycan 2.1824
WDR46 WD repeat domain 46 2.18186
PNOC prepronociceptin 2.18123
LCN1 lipocalin 1 2.18036
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.17571
RNF43 ring finger protein 43 2.16819
CCDC81 coiled-coil domain containing 81 2.16616
GMPS guanine monphosphate synthase 2.16196
GREM1 gremlin 1, DAN family BMP antagonist 2.15586
GCAT glycine C-acetyltransferase 2.1504
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 2.14963
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.14552
MZB1 marginal zone B and B1 cell-specific protein 2.1442
BAK1 BCL2-antagonist/killer 1 2.14262
ANKRD37 ankyrin repeat domain 37 2.14091
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.13666
NOTCH1 notch 1 2.13638
DNASE1 deoxyribonuclease I 2.13174
SAFB scaffold attachment factor B 2.12729
KLHL11 kelch-like family member 11 2.12635
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.12123
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.1196
RFX1 regulatory factor X, 1 (influences HLA class II expression) 2.11829
WNT6 wingless-type MMTV integration site family, member 6 2.11495
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2.11428
KIAA0040 KIAA0040 2.11364
RUVBL1 RuvB-like AAA ATPase 1 2.11276
RIPK4 receptor-interacting serine-threonine kinase 4 2.11223
CLDN3 claudin 3 2.1072
CNTN1 contactin 1 2.09916
UBTF upstream binding transcription factor, RNA polymerase I 2.09553
TWNK twinkle mtDNA helicase 2.09536
SMTN smoothelin 2.09259
CNPY3-GNMT CNPY3-GNMT readthrough 2.09079
TPRA1 transmembrane protein, adipocyte asscociated 1 2.09066
GADD45A growth arrest and DNA-damage-inducible, alpha 2.09014
ADM2 adrenomedullin 2 2.08988
KISS1 KiSS-1 metastasis-suppressor 2.08948
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.08659
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.08165
TGFB3 transforming growth factor, beta 3 2.08159
CLN3 ceroid-lipofuscinosis, neuronal 3 2.08081
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.08037
H1-3 H1.3 linker histone, cluster member 2.07867
ARHGAP4 Rho GTPase activating protein 4 2.07792
EIF5A2 eukaryotic translation initiation factor 5A2 2.07734
STRN4 striatin, calmodulin binding protein 4 2.06884
CRYBA2 crystallin, beta A2 2.06377
TNF tumor necrosis factor 2.06126
PHF10 PHD finger protein 10 2.05694
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta 2.05131
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.05071
MNS1 meiosis-specific nuclear structural 1 2.04857
NT5DC3 5'-nucleotidase domain containing 3 2.04777
NDC80 NDC80 kinetochore complex component 2.04518
RGS14 regulator of G-protein signaling 14 2.04269
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.04217
RENBP renin binding protein 2.04203
DRC11 dynein regulatory complex subunit 11 2.03778
CIAO3 cytosolic iron-sulfur assembly component 3 2.03772
PALM paralemmin 2.03691
RGS16 regulator of G-protein signaling 16 2.03548
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.03543
PTK2B protein tyrosine kinase 2 beta 2.03429
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.0275
CNPY3 canopy FGF signaling regulator 3 2.02395
PRSS50 protease, serine, 50 2.02207
SOX18 SRY (sex determining region Y)-box 18 2.02153
AHDC1 AT hook, DNA binding motif, containing 1 2.01679
REG3A regenerating islet-derived 3 alpha 2.01493
ARL15 ADP-ribosylation factor-like 15 2.01353
DOCK3 dedicator of cytokinesis 3 2.00546
MUC16 mucin 16, cell surface associated 2.00546
REG1B regenerating islet-derived 1 beta 2.00446

decreased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 -5.79516
PRPF4 pre-mRNA processing factor 4 -5.19778
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.87184
TIMP1 TIMP metallopeptidase inhibitor 1 -4.58557
VDAC1 voltage-dependent anion channel 1 -4.32207
OXA1L oxidase (cytochrome c) assembly 1-like -4.31262
RNF167 ring finger protein 167 -4.08038
CD58 CD58 molecule -3.63102
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.48095
CD81 CD81 molecule -3.36454
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.3588
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.30986
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.29698
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -3.22459
MSN moesin -3.14943
MSMO1 methylsterol monooxygenase 1 -3.11827
SNX3 sorting nexin 3 -3.02197
MTERF3 mitochondrial transcription termination factor 3 -3.02146
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.99579
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.96135
FOSL1 FOS-like antigen 1 -2.77065
TMEM9B TMEM9 domain family, member B -2.72958
ITPRID2 ITPR interacting domain containing 2 -2.70902
MRPL17 mitochondrial ribosomal protein L17 -2.66614
TMBIM6 transmembrane BAX inhibitor motif containing 6 -2.65303
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa -2.59463
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.57561
NDEL1 nudE neurodevelopment protein 1-like 1 -2.56032
HSDL2 hydroxysteroid dehydrogenase like 2 -2.53804
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.51108
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.50502
CBR3 carbonyl reductase 3 -2.46951
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.46905
ARF4 ADP-ribosylation factor 4 -2.45895
MRPS33 mitochondrial ribosomal protein S33 -2.45467
TCTA T-cell leukemia translocation altered -2.4282
INPP1 inositol polyphosphate-1-phosphatase -2.42188
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.41596
NLRP2B NLR family pyrin domain containing 2B -2.41369
RTRAF RNA transcription, translation and transport factor -2.41062
SGK1 serum/glucocorticoid regulated kinase 1 -2.40895
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.40833
WDR83OS WD repeat domain 83 opposite strand -2.39057
ADGRE1 adhesion G protein-coupled receptor E1 -2.36882
TMED3 transmembrane emp24 protein transport domain containing 3 -2.3408
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.33713
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.33487
RSU1 Ras suppressor protein 1 -2.33362
TENT5A terminal nucleotidyltransferase 5A -2.31694
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.30166
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.29077
LDHD lactate dehydrogenase D -2.28869
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.27713
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -2.27181
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.23084
TMED9 transmembrane emp24 protein transport domain containing 9 -2.21919
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.21461
HAL histidine ammonia-lyase -2.21375
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -2.21366
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.21322
SYPL1 synaptophysin-like 1 -2.19908
RRAGA Ras-related GTP binding A -2.19778
TM2D3 TM2 domain containing 3 -2.18801
ELAVL1 ELAV like RNA binding protein 1 -2.1868
SYT2 synaptotagmin II -2.18579
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.18494
KDM3A lysine (K)-specific demethylase 3A -2.18487
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.18218
PRDX5 peroxiredoxin 5 -2.18025
MFSD1 major facilitator superfamily domain containing 1 -2.17769
ZNF189 zinc finger protein 189 -2.17577
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.15107
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.1435
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.13442
BDNF brain-derived neurotrophic factor -2.13421
GABARAP GABA(A) receptor-associated protein -2.13306
COTL1 coactosin-like F-actin binding protein 1 -2.12828
MPO myeloperoxidase -2.12749
PYGL phosphorylase, glycogen, liver -2.12522
SELL selectin L -2.12016
CBR1 carbonyl reductase 1 -2.11074
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.10786
ZNF184 zinc finger protein 184 -2.10333
RHOA ras homolog family member A -2.09896
MARF1 meiosis regulator and mRNA stability factor 1 -2.09805
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.09564
GSTA4 glutathione S-transferase alpha 4 -2.08971
SEC31A SEC31 homolog A (S. cerevisiae) -2.08922
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -2.08541
CLTC clathrin, heavy chain (Hc) -2.08329
AKIP1 A kinase (PRKA) interacting protein 1 -2.07747
ADIPOR1 adiponectin receptor 1 -2.07565
TMCO1 transmembrane and coiled-coil domains 1 -2.0711
CST3 cystatin C -2.06841
DAD1 defender against cell death 1 -2.05021
PLAGL1 pleiomorphic adenoma gene-like 1 -2.04612
IL2RB interleukin 2 receptor, beta -2.0432
GTF2A2 general transcription factor IIA, 2, 12kDa -2.03315
CAB39 calcium binding protein 39 -2.03128
FLT3 fms-related tyrosine kinase 3 -2.02824
OXSR1 oxidative stress responsive 1 -2.02407
LRP10 low density lipoprotein receptor-related protein 10 -2.02069
FTL ferritin, light polypeptide -2.01997
YIPF5 Yip1 domain family, member 5 -2.01423
VAMP3 vesicle-associated membrane protein 3 -2.01358
TSPAN3 tetraspanin 3 -2.00453