CRCGN015_MCF10A.WT.HP_24H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 3.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

294 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 5.26673
HBA1 hemoglobin, alpha 1 5.1118
EGR1 early growth response 1 4.59719
GRN granulin 4.26248
FHL2 four and a half LIM domains 2 4.09893
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.05044
MYLK myosin light chain kinase 3.72398
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.58913
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.56312
MVP major vault protein 3.51306
ABHD6 abhydrolase domain containing 6 3.46994
FAT1 FAT atypical cadherin 1 3.44266
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.41008
GHR growth hormone receptor 3.36865
SCCPDH saccharopine dehydrogenase (putative) 3.30646
LRP10 low density lipoprotein receptor-related protein 10 3.28492
ADRB2 adrenoceptor beta 2, surface 3.28039
BLCAP bladder cancer associated protein 3.22042
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.21845
GATA2 GATA binding protein 2 3.2058
CIAO3 cytosolic iron-sulfur assembly component 3 3.18861
QARS1 glutaminyl-tRNA synthetase 1 3.14178
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.13771
ETHE1 ethylmalonic encephalopathy 1 3.09782
CNRIP1 cannabinoid receptor interacting protein 1 3.09406
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.0272
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.98368
ECH1 enoyl CoA hydratase 1, peroxisomal 2.90599
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.89548
PYGL phosphorylase, glycogen, liver 2.84712
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.75205
DENND2D DENN/MADD domain containing 2D 2.74314
FOXO4 forkhead box O4 2.74301
CERS6 ceramide synthase 6 2.71751
AXIN1 axin 1 2.68903
HSPA1A heat shock 70kDa protein 1A 2.64268
CASZ1 castor zinc finger 1 2.64242
ANXA8L1 annexin A8-like 1 2.61708
NOP53 NOP53 ribosome biogenesis factor 2.61695
TNIP1 TNFAIP3 interacting protein 1 2.60491
KDM5D lysine (K)-specific demethylase 5D 2.59834
HBB hemoglobin, beta 2.59383
CXCL2 chemokine (C-X-C motif) ligand 2 2.58623
IL1B interleukin 1, beta 2.55582
GAA glucosidase, alpha; acid 2.55097
KDM5A lysine (K)-specific demethylase 5A 2.53901
HSPA1B heat shock 70kDa protein 1B 2.51009
LETMD1 LETM1 domain containing 1 2.47662
S100A14 S100 calcium binding protein A14 2.45736
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.43562
RAB5B RAB5B, member RAS oncogene family 2.42971
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.40045
EIF4B eukaryotic translation initiation factor 4B 2.37723
TARBP1 TAR (HIV-1) RNA binding protein 1 2.33004
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.32551
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.31289
SNX6 sorting nexin 6 2.30565
PROS1 protein S (alpha) 2.30171
PDLIM1 PDZ and LIM domain 1 2.28607
EIF3G eukaryotic translation initiation factor 3, subunit G 2.27551
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.27013
USP9Y ubiquitin specific peptidase 9, Y-linked 2.26513
HMOX1 heme oxygenase 1 2.26467
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.25518
CEPT1 choline/ethanolamine phosphotransferase 1 2.25262
METRN meteorin, glial cell differentiation regulator 2.24839
RAB13 RAB13, member RAS oncogene family 2.24505
C1S complement component 1, s subcomponent 2.21124
VPS9D1 VPS9 domain containing 1 2.18063
EIF3L eukaryotic translation initiation factor 3, subunit L 2.17478
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 2.16286
C1R complement component 1, r subcomponent 2.16198
IGBP1 immunoglobulin (CD79A) binding protein 1 2.1576
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.15162
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.14219
SPATA20 spermatogenesis associated 20 2.14148
GSTK1 glutathione S-transferase kappa 1 2.12765
TMEM43 transmembrane protein 43 2.11708
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.11098
EIF2D eukaryotic translation initiation factor 2D 2.10786
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.10712
UBA7 ubiquitin-like modifier activating enzyme 7 2.10088
CPNE7 copine VII 2.0981
TMEM50A transmembrane protein 50A 2.08714
AVEN apoptosis, caspase activation inhibitor 2.08579
ZBTB16 zinc finger and BTB domain containing 16 2.08315
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.07533
GLOD4 glyoxalase domain containing 4 2.0714
IRS1 insulin receptor substrate 1 2.05967
MAN2B1 mannosidase, alpha, class 2B, member 1 2.05153
IL18 interleukin 18 2.0467
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.04292
IRX4 iroquois homeobox 4 2.04043
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.04037
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.03892
TLCD3A TLC domain containing 3A 2.03785
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.03485
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.03454
CEMP1 cementum protein 1 2.02236
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.02146
TRIM22 tripartite motif containing 22 2.0207
NIPAL2 NIPA-like domain containing 2 2.01838
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.0177
EBI3 Epstein-Barr virus induced 3 2.01503
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.01231
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.00846
GZMM granzyme M (lymphocyte met-ase 1) 2.00843

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -8.61587
CCNB2 cyclin B2 -8.31752
UBE2C ubiquitin-conjugating enzyme E2C -8.14272
KIF20A kinesin family member 20A -7.66169
PSRC1 proline/serine-rich coiled-coil 1 -7.26509
PLK1 polo-like kinase 1 -6.39117
CDK1 cyclin-dependent kinase 1 -5.93369
BIRC5 baculoviral IAP repeat containing 5 -5.90722
KIF14 kinesin family member 14 -5.78534
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -5.55867
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.44839
CCNA2 cyclin A2 -5.38008
CCNB1 cyclin B1 -5.31693
TOP2A topoisomerase (DNA) II alpha 170kDa -5.03626
KIF4A kinesin family member 4A -4.81364
HMMR hyaluronan-mediated motility receptor (RHAMM) -4.78266
CENPA centromere protein A -4.71218
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -4.65011
CDCA8 cell division cycle associated 8 -4.6144
OIP5 Opa interacting protein 5 -4.5707
NUSAP1 nucleolar and spindle associated protein 1 -4.56627
LBR lamin B receptor -4.50752
DEPDC1 DEP domain containing 1 -4.46773
THAP11 THAP domain containing 11 -4.43643
AURKA aurora kinase A -4.4323
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -4.43061
SMNDC1 survival motor neuron domain containing 1 -4.40422
CDKN3 cyclin-dependent kinase inhibitor 3 -4.34363
NEK2 NIMA-related kinase 2 -4.31306
PIMREG PICALM interacting mitotic regulator -4.12063
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -4.11579
PBK PDZ binding kinase -4.10084
CCDC86 coiled-coil domain containing 86 -4.08247
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -4.0172
PRC1 protein regulator of cytokinesis 1 -3.97732
CEP55 centrosomal protein 55kDa -3.94438
PTTG1 pituitary tumor-transforming 1 -3.84568
SPAG5 sperm associated antigen 5 -3.77
CDCA3 cell division cycle associated 3 -3.76837
HJURP Holliday junction recognition protein -3.75703
FOXM1 forkhead box M1 -3.74774
NCAPH non-SMC condensin I complex, subunit H -3.69297
TROAP trophinin associated protein -3.68341
RPA3 replication protein A3, 14kDa -3.65923
RPL39L ribosomal protein L39-like -3.59192
AURKB aurora kinase B -3.58001
MTFR1 mitochondrial fission regulator 1 -3.57804
GTF2A2 general transcription factor IIA, 2, 12kDa -3.57141
SPC25 SPC25, NDC80 kinetochore complex component -3.55029
CENPE centromere protein E, 312kDa -3.53459
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.49395
HMG20B high mobility group 20B -3.49288
PARPBP PARP1 binding protein -3.45532
STMN1 stathmin 1 -3.41836
CD320 CD320 molecule -3.41119
CBR3 carbonyl reductase 3 -3.37749
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.30025
TTK TTK protein kinase -3.27782
SPDL1 spindle apparatus coiled-coil protein 1 -3.23001
NDC80 NDC80 kinetochore complex component -3.20187
TRAPPC3 trafficking protein particle complex 3 -3.18042
MKI67 marker of proliferation Ki-67 -3.17222
DCK deoxycytidine kinase -3.15918
GOLT1B golgi transport 1B -3.12209
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.11911
TPX2 TPX2, microtubule-associated -3.10078
UBE2S ubiquitin-conjugating enzyme E2S -3.09888
GEMIN2 gem (nuclear organelle) associated protein 2 -3.09261
CENPN centromere protein N -3.05327
SMC4 structural maintenance of chromosomes 4 -3.0414
CDC25C cell division cycle 25C -2.9679
DBF4 DBF4 zinc finger -2.96186
KIF15 kinesin family member 15 -2.94405
CCNF cyclin F -2.9367
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.92984
KLHL7 kelch-like family member 7 -2.9293
TLK2 tousled-like kinase 2 -2.90763
KIF11 kinesin family member 11 -2.86397
CKS1B CDC28 protein kinase regulatory subunit 1B -2.84827
TK1 thymidine kinase 1, soluble -2.82388
KIF18A kinesin family member 18A -2.82041
NLRP2B NLR family pyrin domain containing 2B -2.79444
NCAPD2 non-SMC condensin I complex, subunit D2 -2.79288
KIF18B kinesin family member 18B -2.76379
WDR41 WD repeat domain 41 -2.76102
CMC2 C-x(9)-C motif containing 2 -2.74072
PRR15L proline rich 15-like -2.73042
VDAC1 voltage-dependent anion channel 1 -2.72179
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.69966
NSD2 nuclear receptor binding SET domain protein 2 -2.68421
ERCC6L excision repair cross-complementation group 6-like -2.68017
ZNF211 zinc finger protein 211 -2.66415
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.65882
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.60401
HMGB2 high mobility group box 2 -2.58878
ZNF143 zinc finger protein 143 -2.58085
CEP70 centrosomal protein 70kDa -2.57044
CDC27 cell division cycle 27 -2.56392
TACC3 transforming, acidic coiled-coil containing protein 3 -2.55879
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.55711
EMC9 ER membrane protein complex subunit 9 -2.5411
CKS2 CDC28 protein kinase regulatory subunit 2 -2.53826
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.51934
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.519
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.50153
BLTP3B bridge-like lipid transfer protein family member 3B -2.48807
ARHGAP11A Rho GTPase activating protein 11A -2.47775
DERL2 derlin 2 -2.47088
NCAPG2 non-SMC condensin II complex, subunit G2 -2.44648
BORA bora, aurora kinase A activator -2.42761
CENPS-CORT CENPS-CORT readthrough -2.41941
PFN1 profilin 1 -2.40808
TXNDC9 thioredoxin domain containing 9 -2.40419
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.3954
RACGAP1 Rac GTPase activating protein 1 -2.37881
H2AX H2A.X variant histone -2.37617
HOXC10 homeobox C10 -2.37026
HSPA14 heat shock 70kDa protein 14 -2.36272
CHKA choline kinase alpha -2.36138
GIN1 gypsy retrotransposon integrase 1 -2.35119
KDM6A lysine (K)-specific demethylase 6A -2.34146
GDF15 growth differentiation factor 15 -2.33406
SNRPG small nuclear ribonucleoprotein polypeptide G -2.32898
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.31747
GTSE1 G-2 and S-phase expressed 1 -2.30656
MOCS2 molybdenum cofactor synthesis 2 -2.29825
CYCS cytochrome c, somatic -2.27823
HSPA13 heat shock protein 70kDa family, member 13 -2.25887
MRGBP MRG/MORF4L binding protein -2.25854
HAT1 histone acetyltransferase 1 -2.25479
CCDC59 coiled-coil domain containing 59 -2.24933
COX17 COX17 cytochrome c oxidase copper chaperone -2.22932
DDIT4 DNA-damage-inducible transcript 4 -2.22342
SHCBP1 SHC SH2-domain binding protein 1 -2.22162
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.22118
FAIM Fas apoptotic inhibitory molecule -2.21226
ALX1 ALX homeobox 1 -2.20584
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -2.20141
SAP130 Sin3A-associated protein, 130kDa -2.19516
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.19448
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.19439
SNX10 sorting nexin 10 -2.18557
FEN1 flap structure-specific endonuclease 1 -2.18174
UBA1 ubiquitin-like modifier activating enzyme 1 -2.18057
HMGN2 high mobility group nucleosomal binding domain 2 -2.17298
EMC6 ER membrane protein complex subunit 6 -2.169
APOBEC3A_B APOBEC3A and APOBEC3B deletion hybrid -2.16043
ECD ecdysoneless homolog (Drosophila) -2.15839
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.15813
MANEA mannosidase, endo-alpha -2.1508
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.143
MED27 mediator complex subunit 27 -2.13443
OGFRL1 opioid growth factor receptor-like 1 -2.13283
INSIG1 insulin induced gene 1 -2.12836
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.1211
HAPSTR1 HUWE1 associated protein modifying stress responses -2.12008
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.11851
ECT2 epithelial cell transforming 2 -2.11592
DNA2 DNA replication helicase/nuclease 2 -2.11529
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.11403
MORC3 MORC family CW-type zinc finger 3 -2.11245
PIR pirin (iron-binding nuclear protein) -2.10807
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.09091
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.08983
SEC61B Sec61 beta subunit -2.08505
MRPL35 mitochondrial ribosomal protein L35 -2.08276
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.08181
KIF23 kinesin family member 23 -2.07495
METTL16 methyltransferase like 16 -2.06821
COIL coilin -2.06707
SGPP1 sphingosine-1-phosphate phosphatase 1 -2.0636
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) -2.06271
MCM10 minichromosome maintenance complex component 10 -2.06019
ASF1B anti-silencing function 1B histone chaperone -2.05616
KDM5C lysine (K)-specific demethylase 5C -2.05385
HSF2 heat shock transcription factor 2 -2.05194
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.04913
FGL2 fibrinogen-like 2 -2.04585
RNASE7 ribonuclease, RNase A family, 7 -2.03999
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.03665
TMPO thymopoietin -2.03038
MRPL44 mitochondrial ribosomal protein L44 -2.02973
NUP88 nucleoporin 88kDa -2.02548
SKA1 spindle and kinetochore associated complex subunit 1 -2.02374
ATXN7L1 ataxin 7-like 1 -2.01719
RAD51C RAD51 paralog C -2.00674
ARID4B AT rich interactive domain 4B (RBP1-like) -2.00126