CRCGN015_MCF10A.WT.HP_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

129 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 5.28872
HOXA5 homeobox A5 5.20504
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 5.07873
PDLIM1 PDZ and LIM domain 1 4.18097
NRIP1 nuclear receptor interacting protein 1 4.17381
UGDH UDP-glucose 6-dehydrogenase 3.88467
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.64864
CNRIP1 cannabinoid receptor interacting protein 1 3.5287
AGR2 anterior gradient 2 3.48611
SCCPDH saccharopine dehydrogenase (putative) 3.46687
FGFR4 fibroblast growth factor receptor 4 3.2894
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.13116
IQGAP1 IQ motif containing GTPase activating protein 1 3.04237
VAT1 vesicle amine transport 1 2.99504
SNAP25 synaptosomal-associated protein, 25kDa 2.91934
E2F2 E2F transcription factor 2 2.81454
FHL2 four and a half LIM domains 2 2.80891
RAB4A RAB4A, member RAS oncogene family 2.73286
SMAD3 SMAD family member 3 2.60453
MOK MOK protein kinase 2.53696
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.52262
PLK2 polo-like kinase 2 2.48206
TUBB6 tubulin, beta 6 class V 2.47985
LGI1 leucine-rich, glioma inactivated 1 2.47933
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.47268
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.43673
TSGA10 testis specific, 10 2.40408
TAC1 tachykinin, precursor 1 2.39258
ECH1 enoyl CoA hydratase 1, peroxisomal 2.34469
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.34134
HSPA1A heat shock 70kDa protein 1A 2.33379
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.3295
HELLS helicase, lymphoid-specific 2.30406
ADH6 alcohol dehydrogenase 6 (class V) 2.2865
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.28585
PGLS 6-phosphogluconolactonase 2.28212
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 2.28006
SCG3 secretogranin III 2.24968
GATD3 glutamine amidotransferase class 1 domain containing 3 2.22744
IL1B interleukin 1, beta 2.22297
CLDN10 claudin 10 2.19413
MSRA methionine sulfoxide reductase A 2.15542
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.15378
RPL10L ribosomal protein L10-like 2.1448
ZNF548 zinc finger protein 548 2.13366
QARS1 glutaminyl-tRNA synthetase 1 2.1178
SCGN secretagogin, EF-hand calcium binding protein 2.11045
FBXO31 F-box protein 31 2.09782
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.09334
IGBP1 immunoglobulin (CD79A) binding protein 1 2.08548
MVP major vault protein 2.0854
HMOX1 heme oxygenase 1 2.07727
SIRT3 sirtuin 3 2.06271
RABAC1 Rab acceptor 1 (prenylated) 2.0413
BRCA1 breast cancer 1, early onset 2.03589
HOXA4 homeobox A4 2.02857
GRN granulin 2.01708
CST1 cystatin SN 2.00592
HOXA6 homeobox A6 2.00579
TTPA tocopherol (alpha) transfer protein 2.00486
PYGL phosphorylase, glycogen, liver 2.00399

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -5.30352
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.18861
GOLT1B golgi transport 1B -4.92716
YME1L1 YME1-like 1 ATPase -4.32835
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.20301
DERA deoxyribose-phosphate aldolase (putative) -3.09422
CDK4 cyclin-dependent kinase 4 -3.09361
CCNB2 cyclin B2 -3.04449
GLRX glutaredoxin (thioltransferase) -2.97231
LBR lamin B receptor -2.97185
MSN moesin -2.94717
TRIB3 tribbles pseudokinase 3 -2.83305
SRFBP1 serum response factor binding protein 1 -2.80683
CD320 CD320 molecule -2.75407
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.68268
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.6706
SMNDC1 survival motor neuron domain containing 1 -2.66127
WAC WW domain containing adaptor with coiled-coil -2.64563
CISD1 CDGSH iron sulfur domain 1 -2.63669
GDF15 growth differentiation factor 15 -2.61705
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.60743
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.5966
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.59606
RNFT1-DT RNFT1 divergent transcript -2.58435
GTF2A2 general transcription factor IIA, 2, 12kDa -2.57768
MTERF3 mitochondrial transcription termination factor 3 -2.57727
RINT1 RAD50 interactor 1 -2.54415
AZIN2 antizyme inhibitor 2 -2.53927
DERL2 derlin 2 -2.48284
ELP5 elongator acetyltransferase complex subunit 5 -2.46021
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.45541
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.44928
RAD51C RAD51 paralog C -2.43723
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.39537
MARS1 methionyl-tRNA synthetase 1 -2.39133
CD2 CD2 molecule -2.38999
PSRC1 proline/serine-rich coiled-coil 1 -2.34226
HSPA14 heat shock 70kDa protein 14 -2.31034
NLRP2B NLR family pyrin domain containing 2B -2.28595
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.27724
SMIM10L1 small integral membrane protein 10 like 1 -2.27131
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.26473
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.26059
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.25685
KLHL9 kelch-like family member 9 -2.25677
TLK2 tousled-like kinase 2 -2.17484
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.17461
VBP1 von Hippel-Lindau binding protein 1 -2.17324
NCAPD2 non-SMC condensin I complex, subunit D2 -2.16902
FBN1 fibrillin 1 -2.14588
CKS1B CDC28 protein kinase regulatory subunit 1B -2.13899
OXSR1 oxidative stress responsive 1 -2.13494
TMEM126B transmembrane protein 126B -2.1336
UBL5 ubiquitin-like 5 -2.10628
FAIM Fas apoptotic inhibitory molecule -2.0975
BCAP29 B-cell receptor-associated protein 29 -2.0895
NAXD NAD(P)HX dehydratase -2.08699
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.08605
CD58 CD58 molecule -2.0794
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.07175
INSIG1 insulin induced gene 1 -2.06792
SAR1B secretion associated, Ras related GTPase 1B -2.06365
CYCS cytochrome c, somatic -2.05701
MEIS2 Meis homeobox 2 -2.03994
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.03895
ABITRAM actin binding transcription modulator -2.03606
ELOC elongin C -2.01331
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -2.00366