CRCGN015_MCF10A.WT.HP_24H:K13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aspirin 99.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHEK1 checkpoint kinase 1 5.47447
HOXA5 homeobox A5 4.36285
CCDC92 coiled-coil domain containing 92 3.95727
MAMLD1 mastermind-like domain containing 1 3.91924
CNPY3 canopy FGF signaling regulator 3 3.75827
KLHL21 kelch-like family member 21 3.63818
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.30706
IDE insulin-degrading enzyme 3.21494
KDM5D lysine (K)-specific demethylase 5D 3.20305
NRIP1 nuclear receptor interacting protein 1 3.19079
RPL39L ribosomal protein L39-like 2.83495
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.77543
NOTCH1 notch 1 2.69441
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.67864
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.63667
PRKCD protein kinase C, delta 2.42172
HLA-DRA major histocompatibility complex, class II, DR alpha 2.40429
DDHD2 DDHD domain containing 2 2.38112
PLSCR3 phospholipid scramblase 3 2.36187
COMP cartilage oligomeric matrix protein 2.34837
SOCS5 suppressor of cytokine signaling 5 2.23464
IRX5 iroquois homeobox 5 2.2257
WDR37 WD repeat domain 37 2.22506
PRR15L proline rich 15-like 2.20563
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.18658
TPD52L2 tumor protein D52-like 2 2.16434
FPGS folylpolyglutamate synthase 2.01732

decreased expression

Symbol Name Standardized Value
MSN moesin -3.63398
GDF15 growth differentiation factor 15 -3.54487
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.40875
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.31285
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -3.08501
PARP2 poly (ADP-ribose) polymerase 2 -2.95576
CAB39 calcium binding protein 39 -2.71095
OSGEP O-sialoglycoprotein endopeptidase -2.67529
NVL nuclear VCP-like -2.64746
CCNB1 cyclin B1 -2.63887
B3GAT1 beta-1,3-glucuronyltransferase 1 -2.45926
MSMO1 methylsterol monooxygenase 1 -2.26905
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.21518
H1-4 H1.4 linker histone, cluster member -2.14416
ZNF506 zinc finger protein 506 -2.13759
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.128
RBM34 RNA binding motif protein 34 -2.07799
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -2.04598
H1-3 H1.3 linker histone, cluster member -2.02244
MTERF4 mitochondrial transcription termination factor 4 -2.01082