CRCGN015_MCF10A.WT.HP_24H:K15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aspirin 11.03 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

119 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.07153
STIMATE STIM activating enhancer 5.04747
E2F2 E2F transcription factor 2 5.02823
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.92388
ZNF586 zinc finger protein 586 4.89221
SPAG4 sperm associated antigen 4 4.77996
UBQLN2 ubiquilin 2 4.48834
AGR2 anterior gradient 2 4.43878
GPER1 G protein-coupled estrogen receptor 1 4.42621
COMP cartilage oligomeric matrix protein 4.3987
ZNF134 zinc finger protein 134 4.31158
ZNF211 zinc finger protein 211 3.69871
DENND2D DENN/MADD domain containing 2D 3.60903
CCL2 chemokine (C-C motif) ligand 2 3.57041
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 3.39694
CCDC88C coiled-coil domain containing 88C 3.00179
MICALL1 MICAL-like 1 2.95889
NRBF2 nuclear receptor binding factor 2 2.95439
ZNF551 zinc finger protein 551 2.93241
CNRIP1 cannabinoid receptor interacting protein 1 2.80755
GSTZ1 glutathione S-transferase zeta 1 2.80015
ZNF587B zinc finger protein 587B 2.75811
GLP2R glucagon-like peptide 2 receptor 2.73937
CGRRF1 cell growth regulator with ring finger domain 1 2.67218
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.6128
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.60541
ZNF813 zinc finger protein 813 2.60492
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.59798
FPGS folylpolyglutamate synthase 2.57307
CCR2 chemokine (C-C motif) receptor 2 2.5578
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.54895
DCHS2 dachsous cadherin-related 2 2.50445
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.48681
ZNF419 zinc finger protein 419 2.47622
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.46139
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.45108
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.40055
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.39498
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.38175
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.3397
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.33674
NYNRIN NYN domain and retroviral integrase containing 2.32112
LIM2 lens intrinsic membrane protein 2, 19kDa 2.29088
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.28968
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.28474
GRN granulin 2.28134
PADI4 peptidyl arginine deiminase, type IV 2.28088
ATXN7L1 ataxin 7-like 1 2.27645
TSPAN8 tetraspanin 8 2.26538
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.25707
ZNF606 zinc finger protein 606 2.25172
FLNB filamin B, beta 2.24902
MMP1 matrix metallopeptidase 1 2.24806
FGF16 fibroblast growth factor 16 2.22255
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.21904
PKN1 protein kinase N1 2.19307
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.18796
CATSPERG catsper channel auxiliary subunit gamma 2.17952
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 2.16679
ZNF761 zinc finger protein 761 2.16491
GRAP2 GRB2-related adaptor protein 2 2.15696
POMZP3 POM121 and ZP3 fusion 2.15014
SRD5A3 steroid 5 alpha-reductase 3 2.14712
ZNF329 zinc finger protein 329 2.14249
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.142
ZNF671 zinc finger protein 671 2.13559
OBP2A odorant binding protein 2A 2.13399
PILRA paired immunoglobin-like type 2 receptor alpha 2.13399
CD1D CD1d molecule 2.12741
PDLIM1 PDZ and LIM domain 1 2.12541
CD101 CD101 molecule 2.1254
IL12A interleukin 12A 2.12394
ZNF518A zinc finger protein 518A 2.12207
CFP complement factor properdin 2.11144
ZNF276 zinc finger protein 276 2.09814
ACTL7A actin-like 7A 2.09763
DOK3 docking protein 3 2.09711
AQP6 aquaporin 6, kidney specific 2.09376
RAB3D RAB3D, member RAS oncogene family 2.09281
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.07904
MELTF melanotransferrin 2.07829
SSX5 synovial sarcoma, X breakpoint 5 2.07304
GMPPB GDP-mannose pyrophosphorylase B 2.0721
WNT1 wingless-type MMTV integration site family, member 1 2.06643
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 2.05942
TBXT T-box transcription factor T 2.05886
TEX28 testis expressed 28 2.05859
APOL6 apolipoprotein L, 6 2.05446
FAM110D family with sequence similarity 110, member D 2.03931
MLH3 mutL homolog 3 2.03559
ZNF197 zinc finger protein 197 2.02471
RXFP3 relaxin/insulin-like family peptide receptor 3 2.02141
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.02103
LYPD1 LY6/PLAUR domain containing 1 2.01602
AAMDC adipogenesis associated, Mth938 domain containing 2.01513
LOC128966597 MAL-like protein 2.01252
TMEM144 transmembrane protein 144 2.01235
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.01025
SSTR1 somatostatin receptor 1 2.00966
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 2.00526
CLEC4A C-type lectin domain family 4, member A 2.0044
KLHL35 kelch-like family member 35 2.00404

decreased expression

Symbol Name Standardized Value
PRPF4 pre-mRNA processing factor 4 -3.99543
MTERF3 mitochondrial transcription termination factor 3 -2.98959
PRCP prolylcarboxypeptidase (angiotensinase C) -2.67751
RGS2 regulator of G-protein signaling 2 -2.5076
STAP2 signal transducing adaptor family member 2 -2.36153
FOXK2 forkhead box K2 -2.34285
USP24 ubiquitin specific peptidase 24 -2.32221
BSPRY B-box and SPRY domain containing -2.29046
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 -2.2405
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.23593
TENT4A terminal nucleotidyltransferase 4A -2.23301
PFN2 profilin 2 -2.22052
TRAP1 TNF receptor-associated protein 1 -2.19769
GPN3 GPN-loop GTPase 3 -2.16245
TWIST1 twist family bHLH transcription factor 1 -2.15635
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.1487
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.03582