CRCGN015_MCF10A.WT.HP_24H:K20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description kynurenic-acid 34.54 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

254 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.38677
HLA-DRA major histocompatibility complex, class II, DR alpha 5.18664
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 4.69317
WIF1 WNT inhibitory factor 1 4.68345
LAGE3 L antigen family, member 3 4.46229
PFKL phosphofructokinase, liver 3.82984
GRB7 growth factor receptor-bound protein 7 3.81674
EFNA3 ephrin-A3 3.48441
GATD3 glutamine amidotransferase class 1 domain containing 3 3.41199
FKBP14 FK506 binding protein 14, 22 kDa 3.35479
COMP cartilage oligomeric matrix protein 3.31208
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3.29458
CCL2 chemokine (C-C motif) ligand 2 3.15791
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.14183
PGAP3 post-GPI attachment to proteins 3 3.13572
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 3.1206
TRAPPC10 trafficking protein particle complex 10 3.00027
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough 2.92297
NRBP1 nuclear receptor binding protein 1 2.85076
SMG9 SMG9 nonsense mediated mRNA decay factor 2.80932
STK38 serine/threonine kinase 38 2.7982
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.78246
DPEP1 dipeptidase 1 (renal) 2.77348
ZFP36L2 ZFP36 ring finger protein-like 2 2.71011
MUC1 mucin 1, cell surface associated 2.70871
ACAA1 acetyl-CoA acyltransferase 1 2.64111
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.64067
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 2.63874
CXCL3 chemokine (C-X-C motif) ligand 3 2.63621
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 2.63608
PLXNB1 plexin B1 2.63332
PALM paralemmin 2.62556
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.61066
PLAGL1 pleiomorphic adenoma gene-like 1 2.60494
UBQLN2 ubiquilin 2 2.60384
PDE9A phosphodiesterase 9A 2.59685
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.58233
NUAK2 NUAK family, SNF1-like kinase, 2 2.58058
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 2.57921
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.57327
AOC1 amine oxidase, copper containing 1 2.57042
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.5615
RING1 ring finger protein 1 2.55884
MTG1 mitochondrial ribosome-associated GTPase 1 2.54369
MSH5 mutS homolog 5 2.51529
STK10 serine/threonine kinase 10 2.49602
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.47666
SOBP sine oculis binding protein homolog (Drosophila) 2.45941
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.45008
WNT5B wingless-type MMTV integration site family, member 5B 2.4462
FBXL6 F-box and leucine-rich repeat protein 6 2.42739
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.42227
LGALS4 lectin, galactoside-binding, soluble, 4 2.41098
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 2.39903
BAG6 BCL2-associated athanogene 6 2.39262
ALOX12 arachidonate 12-lipoxygenase 2.39046
STARD3 StAR-related lipid transfer (START) domain containing 3 2.384
IGLL1 immunoglobulin lambda-like polypeptide 1 2.37835
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.37466
METRN meteorin, glial cell differentiation regulator 2.37157
CCL11 chemokine (C-C motif) ligand 11 2.37127
ADM adrenomedullin 2.37028
BTK Bruton agammaglobulinemia tyrosine kinase 2.35788
HSF1 heat shock transcription factor 1 2.35425
PSKH1 protein serine kinase H1 2.33481
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.32442
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.32252
ZNF768 zinc finger protein 768 2.32155
NBAS neuroblastoma amplified sequence 2.32119
ZMIZ2 zinc finger, MIZ-type containing 2 2.32037
CNOT3 CCR4-NOT transcription complex, subunit 3 2.31876
UMOD uromodulin 2.31375
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.30879
TPRA1 transmembrane protein, adipocyte asscociated 1 2.30444
ATP10D ATPase, class V, type 10D 2.29753
SLC38A10 solute carrier family 38, member 10 2.2914
RUSF1 RUS family member 1 2.28151
LOC102723996 ICOS ligand 2.27283
ACOX2 acyl-CoA oxidase 2, branched chain 2.26916
JUP junction plakoglobin 2.26899
MCTP1 multiple C2 domains, transmembrane 1 2.26413
ICAM1 intercellular adhesion molecule 1 2.26268
MRPS18A mitochondrial ribosomal protein S18A 2.257
KREMEN2 kringle containing transmembrane protein 2 2.25447
PRR16 proline rich 16 2.24265
OGFR opioid growth factor receptor 2.23925
CLIP2 CAP-GLY domain containing linker protein 2 2.23666
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.23096
CTSO cathepsin O 2.22748
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.21136
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.21049
MARK4 MAP/microtubule affinity-regulating kinase 4 2.20701
COL18A1 collagen, type XVIII, alpha 1 2.19986
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.18936
SULF1 sulfatase 1 2.18927
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.1889
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.18793
TMEM176A transmembrane protein 176A 2.17866
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 2.17832
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.16968
GJA1 gap junction protein, alpha 1, 43kDa 2.16238
RANGAP1 Ran GTPase activating protein 1 2.16117
YEATS2 YEATS domain containing 2 2.15467
SH2B2 SH2B adaptor protein 2 2.14235
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.13929
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.13691
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.13653
DCTN1 dynactin 1 2.13651
CUEDC1 CUE domain containing 1 2.12715
MYO18A myosin XVIIIA 2.12645
KLHDC3 kelch domain containing 3 2.12107
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.11352
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 2.11262
ACTL8 actin-like 8 2.10376
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 2.1
PCNT pericentrin 2.09206
PRRC2A proline-rich coiled-coil 2A 2.0902
CIAO3 cytosolic iron-sulfur assembly component 3 2.08934
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 2.08625
CRELD2 cysteine-rich with EGF-like domains 2 2.07928
CNKSR1 connector enhancer of kinase suppressor of Ras 1 2.07922
ADAM15 ADAM metallopeptidase domain 15 2.07906
NKX3-2 NK3 homeobox 2 2.07896
CAPN1 calpain 1, (mu/I) large subunit 2.07836
TM4SF5 transmembrane 4 L six family member 5 2.07745
GALC galactosylceramidase 2.07592
CDX2 caudal type homeobox 2 2.07321
LLGL2 lethal giant larvae homolog 2 (Drosophila) 2.06366
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.06358
PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.0634
EDC4 enhancer of mRNA decapping 4 2.06137
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.05889
TERT telomerase reverse transcriptase 2.05867
CCNA1 cyclin A1 2.05815
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.0567
SLC12A9 solute carrier family 12, member 9 2.04607
IPO13 importin 13 2.04137
OLFM4 olfactomedin 4 2.03949
SAP25 Sin3A-associated protein, 25kDa 2.03685
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 2.03609
EHBP1L1 EH domain binding protein 1-like 1 2.03573
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.03376
VCAM1 vascular cell adhesion molecule 1 2.03302
HPCA hippocalcin 2.02924
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 2.02348
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.02154
CMTR1 cap methyltransferase 1 2.01848
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.01494
EFNA4 ephrin-A4 2.01399
MTA1 metastasis associated 1 2.00568

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -5.40244
PARP2 poly (ADP-ribose) polymerase 2 -5.30348
ISOC1 isochorismatase domain containing 1 -5.10707
KIF14 kinesin family member 14 -5.02506
HMG20B high mobility group 20B -4.54038
HSPA8 heat shock 70kDa protein 8 -4.22379
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -4.10316
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.05621
THAP11 THAP domain containing 11 -3.61511
PCCB propionyl CoA carboxylase, beta polypeptide -3.37524
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.37115
MSMO1 methylsterol monooxygenase 1 -3.23235
SAR1B secretion associated, Ras related GTPase 1B -3.21579
CAB39 calcium binding protein 39 -3.17403
RNF4 ring finger protein 4 -3.16928
NGRN neugrin, neurite outgrowth associated -3.04334
EIF5 eukaryotic translation initiation factor 5 -3.01997
FASN fatty acid synthase -2.92497
RTRAF RNA transcription, translation and transport factor -2.85622
CETN2 centrin, EF-hand protein, 2 -2.6724
INPP1 inositol polyphosphate-1-phosphatase -2.58321
USPL1 ubiquitin specific peptidase like 1 -2.54957
MORF4L2 mortality factor 4 like 2 -2.51269
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.5103
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.50542
TCTA T-cell leukemia translocation altered -2.50365
NPY1R neuropeptide Y receptor Y1 -2.48747
LDHD lactate dehydrogenase D -2.4865
ASDURF ASNSD1 upstream open reading frame -2.48579
ENOPH1 enolase-phosphatase 1 -2.46888
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.45012
RPP30 ribonuclease P/MRP 30kDa subunit -2.40368
METTL18 methyltransferase like 18 -2.39515
TEFM transcription elongation factor, mitochondrial -2.37792
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -2.36087
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -2.35401
ISCU iron-sulfur cluster assembly enzyme -2.34438
OSGEP O-sialoglycoprotein endopeptidase -2.343
SYPL1 synaptophysin-like 1 -2.34116
PRMT5 protein arginine methyltransferase 5 -2.33778
MRPL3 mitochondrial ribosomal protein L3 -2.31775
RAI1 retinoic acid induced 1 -2.30681
TEX30 testis expressed 30 -2.30045
RAI14 retinoic acid induced 14 -2.29671
TMEM135 transmembrane protein 135 -2.29321
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.29283
METTL17 methyltransferase like 17 -2.28616
OXA1L oxidase (cytochrome c) assembly 1-like -2.28249
FADD Fas (TNFRSF6)-associated via death domain -2.28009
OTUD3 OTU deubiquitinase 3 -2.25502
SLC25A46 solute carrier family 25, member 46 -2.24108
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.23513
GTF2A2 general transcription factor IIA, 2, 12kDa -2.21951
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.2177
TM9SF2 transmembrane 9 superfamily member 2 -2.21494
OAZ1 ornithine decarboxylase antizyme 1 -2.21362
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.21352
HSPA1A heat shock 70kDa protein 1A -2.21284
COPS8 COP9 signalosome subunit 8 -2.20799
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.20007
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.19263
HSPE1 heat shock 10kDa protein 1 -2.17976
CHRDL1 chordin-like 1 -2.1699
CLCN5 chloride channel, voltage-sensitive 5 -2.16707
TENT5A terminal nucleotidyltransferase 5A -2.15822
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.14325
TM9SF1 transmembrane 9 superfamily member 1 -2.13821
NPY5R neuropeptide Y receptor Y5 -2.1361
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.13068
PELO pelota homolog (Drosophila) -2.12478
RNF11 ring finger protein 11 -2.12418
TMED7 transmembrane emp24 protein transport domain containing 7 -2.12322
CCDC90B coiled-coil domain containing 90B -2.12082
CAVIN2 caveolae associated protein 2 -2.12037
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.11765
CORO1C coronin, actin binding protein, 1C -2.1151
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.10534
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.10255
TXNDC9 thioredoxin domain containing 9 -2.09353
NOP10 NOP10 ribonucleoprotein -2.08751
FZD4 frizzled class receptor 4 -2.08532
DCTN4 dynactin 4 (p62) -2.0835
KIAA0232 KIAA0232 -2.0818
HEATR1 HEAT repeat containing 1 -2.07624
BZW1 basic leucine zipper and W2 domains 1 -2.0724
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.05851
BASP1 brain abundant, membrane attached signal protein 1 -2.05227
IL17B interleukin 17B -2.05122
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.04645
CRLF3 cytokine receptor-like factor 3 -2.04406
PGRMC1 progesterone receptor membrane component 1 -2.03805
SC5D sterol-C5-desaturase -2.03608
MRPS14 mitochondrial ribosomal protein S14 -2.03497
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.02844
TOM1L1 target of myb1 (chicken)-like 1 -2.02783
SMIM29 small integral membrane protein 29 -2.02684
FAM168A family with sequence similarity 168, member A -2.02581
GIN1 gypsy retrotransposon integrase 1 -2.02493
PTS 6-pyruvoyltetrahydropterin synthase -2.02219
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -2.02119
PFDN1 prefoldin subunit 1 -2.0173
SEPTIN2 septin 2 -2.01542
NCK2 NCK adaptor protein 2 -2.01399
BABAM1 BRISC and BRCA1 A complex member 1 -2.0073