CRCGN015_MCF10A.WT.HP_24H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(2-chloroethyl) phosphate 100.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 4.14399
MAMLD1 mastermind-like domain containing 1 3.73478
STAP2 signal transducing adaptor family member 2 3.72574
SESN1 sestrin 1 3.54662
SNAP25 synaptosomal-associated protein, 25kDa 3.27561
ZFP37 ZFP37 zinc finger protein 2.64664
HBA1 hemoglobin, alpha 1 2.26254
NSG2 neuronal vesicle trafficking associated 2 2.23642
AGR2 anterior gradient 2 2.213
COL11A1 collagen, type XI, alpha 1 2.14819
RGS7 regulator of G-protein signaling 7 2.11388
CRYAB crystallin, alpha B 2.09974
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.07952
NUCB2 nucleobindin 2 2.05234
ARHGAP24 Rho GTPase activating protein 24 2.04173
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.03475
CNTLN centlein, centrosomal protein 2.02245
ABI3BP ABI family, member 3 (NESH) binding protein 2.01588
ZIM2 zinc finger, imprinted 2 2.00842

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -4.16614
MSN moesin -4.04039
BAG3 BCL2-associated athanogene 3 -3.92647
UFM1 ubiquitin-fold modifier 1 -3.54014
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.48012
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.43451
RXYLT1 ribitol xylosyltransferase 1 -3.25031
CAPRIN2 caprin family member 2 -3.18966
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.15319
TIMP1 TIMP metallopeptidase inhibitor 1 -3.12954
TSPAN4 tetraspanin 4 -2.72745
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.67959
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.63429
NRIP1 nuclear receptor interacting protein 1 -2.60913
UBE3C ubiquitin protein ligase E3C -2.47339
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.45263
CFAP298 cilia and flagella associated protein 298 -2.424
RAP1B RAP1B, member of RAS oncogene family -2.19037
CANT1 calcium activated nucleotidase 1 -2.18878
VWF von Willebrand factor -2.1659
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -2.13521
EXOSC4 exosome component 4 -2.13193
LAMP3 lysosomal-associated membrane protein 3 -2.08027
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.06883
CDH5 cadherin 5, type 2 (vascular endothelium) -2.02978
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.02149