| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-phenyl-p-phenylenediamine.hcl 98.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
| Similar Terms | |
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174 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:L04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GLRX | glutaredoxin (thioltransferase) | 6.31727 |
| STXBP1 | syntaxin binding protein 1 | 6.06375 |
| HMOX1 | heme oxygenase 1 | 5.62965 |
| RGS2 | regulator of G-protein signaling 2 | 5.50137 |
| TXNRD1 | thioredoxin reductase 1 | 4.81082 |
| AMDHD2 | amidohydrolase domain containing 2 | 4.71044 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 4.4733 |
| WIF1 | WNT inhibitory factor 1 | 4.10185 |
| OXSR1 | oxidative stress responsive 1 | 4.02378 |
| CTSL | cathepsin L | 3.78914 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 3.75091 |
| NUCB2 | nucleobindin 2 | 3.74522 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.73706 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 3.71935 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 3.63893 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 3.47272 |
| MAMLD1 | mastermind-like domain containing 1 | 3.46281 |
| TRIB3 | tribbles pseudokinase 3 | 3.1598 |
| CNPY3 | canopy FGF signaling regulator 3 | 3.14565 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 3.13283 |
| SLC16A6 | solute carrier family 16, member 6 | 3.09463 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 3.03683 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 2.97509 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.96749 |
| NPC1 | Niemann-Pick disease, type C1 | 2.94689 |
| GARS1 | glycyl-tRNA synthetase 1 | 2.82294 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.81512 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 2.81447 |
| FOXO4 | forkhead box O4 | 2.75924 |
| DUSP4 | dual specificity phosphatase 4 | 2.71976 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 2.69916 |
| AVPI1 | arginine vasopressin-induced 1 | 2.6951 |
| SQSTM1 | sequestosome 1 | 2.57814 |
| PLK3 | polo-like kinase 3 | 2.51318 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.5084 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.49976 |
| INSL4 | insulin-like 4 (placenta) | 2.49509 |
| ANO10 | anoctamin 10 | 2.48964 |
| PHGDH | phosphoglycerate dehydrogenase | 2.47692 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 2.43413 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 2.3984 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | 2.39191 |
| TUBB6 | tubulin, beta 6 class V | 2.39186 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.34992 |
| MVP | major vault protein | 2.34415 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 2.32825 |
| DUSP5 | dual specificity phosphatase 5 | 2.32199 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 2.32099 |
| GMPPA | GDP-mannose pyrophosphorylase A | 2.30181 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.28226 |
| FGFR4 | fibroblast growth factor receptor 4 | 2.27365 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 2.26063 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 2.2606 |
| ORMDL2 | ORMDL sphingolipid biosynthesis regulator 2 | 2.2329 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 2.22164 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 2.21914 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 2.21539 |
| FKBP11 | FK506 binding protein 11, 19 kDa | 2.21391 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 2.21212 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 2.18881 |
| CAMTA2 | calmodulin binding transcription activator 2 | 2.18084 |
| IER3 | immediate early response 3 | 2.17064 |
| CGB8 | chorionic gonadotropin, beta polypeptide 8 | 2.16615 |
| GRWD1 | glutamate-rich WD repeat containing 1 | 2.16403 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.16113 |
| PRR13 | proline rich 13 | 2.14281 |
| CHEK1 | checkpoint kinase 1 | 2.1424 |
| SLC67A1 | solute carrier family 67 member 1 | 2.11575 |
| PLEC | plectin | 2.11106 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 2.10746 |
| PYGB | phosphorylase, glycogen; brain | 2.07071 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.06847 |
| SSTR5 | somatostatin receptor 5 | 2.06448 |
| SQOR | sulfide quinone oxidoreductase | 2.05764 |
| ATOSB | atos homolog B | 2.05554 |
| SLC50A1 | solute carrier family 50 (sugar efflux transporter), member 1 | 2.05388 |
| GTPBP2 | GTP binding protein 2 | 2.05306 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.05118 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 2.04441 |
| HMGA2 | high mobility group AT-hook 2 | 2.04201 |
| VAT1 | vesicle amine transport 1 | 2.03211 |
| TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 | 2.03159 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 2.01869 |
| OSBPL10 | oxysterol binding protein-like 10 | 2.01824 |
| MT1M | metallothionein 1M | 2.01669 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 2.01079 |
| VAMP8 | vesicle-associated membrane protein 8 | 2.01055 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 2.00879 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 2.00413 |
| GBA1 | glucosylceramidase beta 1 | 2.00084 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BID | BH3 interacting domain death agonist | -5.55955 |
| HOXA5 | homeobox A5 | -5.19276 |
| MCM3 | minichromosome maintenance complex component 3 | -4.63069 |
| CDC45 | cell division cycle 45 | -4.57446 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -4.5464 |
| SMNDC1 | survival motor neuron domain containing 1 | -3.58332 |
| CIRBP | cold inducible RNA binding protein | -3.45491 |
| STMN1 | stathmin 1 | -3.34361 |
| CD320 | CD320 molecule | -3.33826 |
| CDK4 | cyclin-dependent kinase 4 | -3.28028 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -3.24615 |
| WASHC5 | WASH complex subunit 5 | -3.14167 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -3.12006 |
| EBNA1BP2 | EBNA1 binding protein 2 | -2.93662 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.89583 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.856 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.80668 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -2.76061 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.72644 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.71891 |
| HADH | hydroxyacyl-CoA dehydrogenase | -2.68561 |
| ZNF329 | zinc finger protein 329 | -2.68211 |
| HOXA4 | homeobox A4 | -2.66671 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.65512 |
| CYCS | cytochrome c, somatic | -2.58354 |
| SESN1 | sestrin 1 | -2.57848 |
| BZW2 | basic leucine zipper and W2 domains 2 | -2.55419 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -2.53729 |
| ZNF606 | zinc finger protein 606 | -2.5365 |
| PCNA | proliferating cell nuclear antigen | -2.52797 |
| AP3M2 | adaptor-related protein complex 3, mu 2 subunit | -2.47892 |
| RLIG1 | RNA 5'-phosphate and 3'-OH ligase 1 | -2.46514 |
| COG2 | component of oligomeric golgi complex 2 | -2.46462 |
| LBR | lamin B receptor | -2.43034 |
| CA9 | carbonic anhydrase IX | -2.42398 |
| POLE3 | polymerase (DNA directed), epsilon 3, accessory subunit | -2.40017 |
| SNRNP40 | small nuclear ribonucleoprotein 40kDa (U5) | -2.39235 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -2.3652 |
| ZNF274 | zinc finger protein 274 | -2.33819 |
| DCK | deoxycytidine kinase | -2.33301 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | -2.32888 |
| SF3A3 | splicing factor 3a, subunit 3, 60kDa | -2.32392 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -2.31348 |
| DPH2 | DPH2 homolog (S. cerevisiae) | -2.29209 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -2.29147 |
| HDAC2 | histone deacetylase 2 | -2.27811 |
| MRPL12 | mitochondrial ribosomal protein L12 | -2.27391 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.24818 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -2.24666 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -2.23416 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -2.23074 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -2.22693 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -2.21845 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -2.21775 |
| LSM2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.20474 |
| EID1 | EP300 interacting inhibitor of differentiation 1 | -2.19799 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | -2.19305 |
| RPIA | ribose 5-phosphate isomerase A | -2.18916 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -2.18411 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.16921 |
| CDK1 | cyclin-dependent kinase 1 | -2.16374 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -2.13931 |
| TP53 | tumor protein p53 | -2.13702 |
| NUP133 | nucleoporin 133kDa | -2.13433 |
| PRPF31 | pre-mRNA processing factor 31 | -2.11661 |
| LRRC40 | leucine rich repeat containing 40 | -2.10863 |
| STOML2 | stomatin (EPB72)-like 2 | -2.1012 |
| SIVA1 | SIVA1, apoptosis-inducing factor | -2.07563 |
| LMNB1 | lamin B1 | -2.05781 |
| NDUFB6 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa | -2.05661 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.05617 |
| TMEM109 | transmembrane protein 109 | -2.05603 |
| ZNF26 | zinc finger protein 26 | -2.05217 |
| ISOC2 | isochorismatase domain containing 2 | -2.05187 |
| ADI1 | acireductone dioxygenase 1 | -2.0499 |
| JAG2 | jagged 2 | -2.049 |
| DPYD | dihydropyrimidine dehydrogenase | -2.03642 |
| STAB1 | stabilin 1 | -2.03188 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.02627 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | -2.0245 |
| ELP5 | elongator acetyltransferase complex subunit 5 | -2.01662 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -2.00915 |
| LZTFL1 | leucine zipper transcription factor-like 1 | -2.00613 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -2.00021 |
