CRCGN015_MCF10A.WT.HP_24H:L05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-phenyl-p-phenylenediamine.hcl 32.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:L05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IGHMBP2 immunoglobulin mu binding protein 2 4.39893
TBX2 T-box 2 4.38928
KCTD5 potassium channel tetramerization domain containing 5 3.9449
SNAP25 synaptosomal-associated protein, 25kDa 3.90513
CXCR4 chemokine (C-X-C motif) receptor 4 3.59726
SSBP2 single-stranded DNA binding protein 2 3.58836
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.10425
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.57335
MAMLD1 mastermind-like domain containing 1 2.53172
ACAA1 acetyl-CoA acyltransferase 1 2.38138
RGS2 regulator of G-protein signaling 2 2.28037
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.20813
DMAC2L distal membrane arm assembly component 2 like 2.20553
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.19848
STXBP1 syntaxin binding protein 1 2.16241
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.14972
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.11716
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.11493
GHITM growth hormone inducible transmembrane protein 2.05828

decreased expression

Symbol Name Standardized Value
C2CD5 C2 calcium-dependent domain containing 5 -4.11991
CD81 CD81 molecule -3.84624
CD58 CD58 molecule -3.79239
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.19578
TRIB3 tribbles pseudokinase 3 -2.68514
PSRC1 proline/serine-rich coiled-coil 1 -2.67548
UBE2C ubiquitin-conjugating enzyme E2C -2.53033
NCAPD2 non-SMC condensin I complex, subunit D2 -2.31075
MMP13 matrix metallopeptidase 13 -2.13406
NISCH nischarin -2.03625
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.03325
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.0081