CRCGN015_MCF10A.WT.HP_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iq 31.94 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COQ8A coenzyme Q8A 4.3299
GATA2 GATA binding protein 2 4.13896
MAMLD1 mastermind-like domain containing 1 4.0283
PDIA5 protein disulfide isomerase family A, member 5 3.815
GPER1 G protein-coupled estrogen receptor 1 3.7222
COMP cartilage oligomeric matrix protein 3.61529
MSRA methionine sulfoxide reductase A 3.2252
METRN meteorin, glial cell differentiation regulator 3.12935
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.05498
HBA1 hemoglobin, alpha 1 2.96377
ACAA1 acetyl-CoA acyltransferase 1 2.93713
LOC102724023 ES1 protein homolog, mitochondrial 2.48576
OLFML2B olfactomedin-like 2B 2.36118
TBX2 T-box 2 2.28925
PXMP2 peroxisomal membrane protein 2, 22kDa 2.25475
AGR2 anterior gradient 2 2.23843
PRKCD protein kinase C, delta 2.22111
FTO fat mass and obesity associated 2.13742
WDR6 WD repeat domain 6 2.10395
MOK MOK protein kinase 2.06663
MAPT microtubule-associated protein tau 2.0424
PGM3 phosphoglucomutase 3 2.02452
GRN granulin 2.02371
GPX7 glutathione peroxidase 7 2.01033

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.99778
STMN1 stathmin 1 -3.76312
GDF15 growth differentiation factor 15 -3.6733
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.61381
UBE3C ubiquitin protein ligase E3C -3.28113
MTERF3 mitochondrial transcription termination factor 3 -3.1841
TIMP1 TIMP metallopeptidase inhibitor 1 -3.07298
TKT transketolase -3.00286
OSTM1 osteopetrosis associated transmembrane protein 1 -2.51684
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.46625
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -2.42512
SV2B synaptic vesicle glycoprotein 2B -2.38115
SQSTM1 sequestosome 1 -2.33426
GPATCH1 G patch domain containing 1 -2.28525
OVGP1 oviductal glycoprotein 1, 120kDa -2.27882
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 -2.23641
MCTP1 multiple C2 domains, transmembrane 1 -2.21178
KLHDC2 kelch domain containing 2 -2.20054
EMC3 ER membrane protein complex subunit 3 -2.19368
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.17652
ACTL7A actin-like 7A -2.13665
AKAP4 A kinase (PRKA) anchor protein 4 -2.10508
TLE4 transducin-like enhancer of split 4 -2.07298
ATP11B ATPase, class VI, type 11B -2.04463
ATP10B ATPase, class V, type 10B -2.02937
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.00154