CRCGN015_MCF10A.WT.HP_24H:L14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description etodolac 33.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:L14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IGHMBP2 immunoglobulin mu binding protein 2 4.61119
COMP cartilage oligomeric matrix protein 4.38229
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.94996
C2CD2 C2 calcium-dependent domain containing 2 3.84011
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.82329
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.41636
NRBF2 nuclear receptor binding factor 2 2.23032
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.11882
MELK maternal embryonic leucine zipper kinase 2.04643
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.03655
FADD Fas (TNFRSF6)-associated via death domain 2.03265
SMAD2 SMAD family member 2 2.00065

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -5.91833
HAT1 histone acetyltransferase 1 -3.73643
ADI1 acireductone dioxygenase 1 -3.56719
BPHL biphenyl hydrolase-like (serine hydrolase) -3.42632
SCYL3 SCY1-like 3 (S. cerevisiae) -2.95989
TENT4A terminal nucleotidyltransferase 4A -2.92352
GADD45B growth arrest and DNA-damage-inducible, beta -2.67098
MACF1 microtubule-actin crosslinking factor 1 -2.36427
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.33064
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.2794
TUBB6 tubulin, beta 6 class V -2.16308
EMX2 empty spiracles homeobox 2 -2.02771